Shin Mi-Yeon, Lee Sunggyu, Choi Hyeyoung, Jeong Da-In, Moon Hyo-Bang, Kim Sungkyoon
Graduate School of Public Health, Seoul National University, Seoul 151-742, South Korea.
Department of Marine Science and Convergent Technology, Hanyang University, Ansan 426-791, South Korea.
Food Chem Toxicol. 2017 Apr;102:198-203. doi: 10.1016/j.fct.2017.01.027. Epub 2017 Jan 31.
Although several studies have conducted maternal transfer of individual PBDE congener in experimental animals, there is a paucity of research on differences in maternal transfer of PBDE congeners. The purpose of the study was to investigate and compare placental and lactational transfer of BDE 47, -209 and its metabolites in rat dam-offspring pairs following repeated administration of BDE 47 and -209. C-BDE 47, BDE 209 and its debrominated congeners were detected both in dam serum and offspring body, which indicates that PBDEs can be maternally transferred. In addition, BDE 196 and -197 appeared in offspring body earlier than in maternal serum, which suggests that debromination can be occur in offspring body. BDE 209 increased in both dam and offspring while levels of C-BDE 47 was not increased in dam serum. 13C-BDE 47 seems to be stored in breast milk rather than in maternal serum, which can be assumed through the drastic increase of the congener in suckling pups. The magnitude of lactational transfer of the administered congeners was greater than that of placental transfer. And C-BDE 47 was relatively more transferred to suckling pups than BDE 209 through breastfeeding.
尽管已有多项研究在实验动物中开展了多溴二苯醚（PBDE）单一同系物的母体转移研究，但关于PBDE同系物母体转移差异的研究却很少。本研究的目的是在大鼠母仔对中，重复给予BDE 47和BDE 209后，研究并比较BDE 47、BDE 209及其代谢产物的胎盘转移和泌乳转移情况。在母鼠血清和仔鼠体内均检测到了碳-13标记的BDE 47、BDE 209及其脱溴同系物，这表明PBDEs能够发生母体转移。此外，BDE 196和BDE 197在仔鼠体内出现的时间早于母鼠血清，这表明脱溴过程可能发生在仔鼠体内。母鼠和仔鼠体内的BDE 209均有所增加，而母鼠血清中碳-13标记的BDE 47水平并未升高。碳-13标记的BDE 47似乎储存在母乳中而非母鼠血清中，这可以通过哺乳幼崽体内该同系物的急剧增加来推断。所给药同系物的泌乳转移量大于胎盘转移量。并且通过母乳喂养，碳-13标记的BDE 47相对BDE 209而言，更多地转移到了哺乳幼崽体内。
