State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China.
J Hazard Mater. 2013 Apr 15;250-251:115-21. doi: 10.1016/j.jhazmat.2013.01.061. Epub 2013 Feb 4.
Widespread human exposure to phenols has been documented recently, and some phenols which are potential endocrine disruptors have demonstrated adverse effects on male reproduction in animal and in vitro studies. However, implications about exposure to phenols and male infertility are scarce in humans. Case-control study of 877 idiopathic infertile men and 713 fertile controls was conducted. Urinary levels of bisphenol A, benzophenone-3, pentachlorophenol, triclosan, 4-tert-octylphenol (4-t-OP), 4-n-octylphenol (4-n-OP) and 4-n-nonylphenol (4-n-NP) and semen parameters were measured. After multivariate adjustment, we found 4-t-OP, 4-n-OP and 4-n-NP exposure was associated with idiopathic male infertility (p-value for trend: <0.0001, 0.014 and 0.001, respectively). Aside from these associations, 4-t-OP and 4-n-NP exposure was also associated with idiopathic male infertility with abnormal semen parameters. Moreover, we observed significant associations between sum alkylphenols (APs) exposure and idiopathic male infertility. There were no relationships between exposure to other phenols and idiopathic male infertility in the present study. Our study provides the first evidence that exposure to APs (4-t-OP, 4-n-OP and 4-n-NP) is associated with idiopathic male infertility.
最近有文献记录表明，人类广泛接触到酚类物质，一些具有潜在内分泌干扰作用的酚类物质在动物和体外研究中已显示出对男性生殖的不良影响。然而，关于人类接触酚类物质与男性不育之间的关系的研究还很少。本研究对 877 名特发性不育男性和 713 名生育能力正常的对照进行了病例对照研究。测量了尿液中的双酚 A、二苯甲酮-3、五氯酚、三氯生、4-叔辛基酚（4-t-OP）、4-正辛基酚（4-n-OP）和 4-正壬基酚（4-n-NP）水平以及精液参数。经过多变量调整后，我们发现 4-t-OP、4-n-OP 和 4-n-NP 暴露与特发性男性不育有关（趋势检验 p 值：<0.0001、0.014 和 0.001）。除了这些关联，4-t-OP 和 4-n-NP 暴露还与特发性男性不育伴有精液参数异常有关。此外，我们还观察到烷基酚（APs）总暴露与特发性男性不育之间存在显著关联。在本研究中，其他酚类物质的暴露与特发性男性不育之间没有关系。本研究首次提供了证据，表明接触 APs（4-t-OP、4-n-OP 和 4-n-NP）与特发性男性不育有关。
