Cai Y, Sun R, He K-F, Zhao Y-F, Zhao J-H
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, 237, LuoYu Road, Wuhan, 430079, P. R. China,
Med Oral Patol Oral Cir Bucal. 2017 Mar 1;22(2):e214-e218. doi: 10.4317/medoral.21422.
Relapse of granulomatous epulis is common after surgery because of local irritations, hormonal level in vivo, or incomplete resection. Currently, if recurrence occurs, then extraction of the teeth adjacent to the lesion is commonly performed, which may influence the aesthetics or masticatory function. Thus, a more effective and less aggressive treatment method is urgently demanded, particularly for the recurring lesion. This study investigated the effects of the intralesional pingyangmycin (PYM) injections for the recurrent granulomatous epulis and assessed the complications.
A total of 16 patients with recurrent granulomatous epulis underwent intralesional PYM injections, between July 2010 and June 2014. The effects and complications of the treatment were retrospectively reviewed.
The total number of injections performed was 48 (for all patients). The median number of injections per patient was three (range, two to four). All cases completely recovered with no recurrence and resorption of the alveolar bone after a follow-up of more than 12 months. The complications included slight bleeding, local swelling and pain following injection. All these symptoms resolved 7 to 10 days after the injection.
In summary, intralesional PYM injections may be a preferred option for recurring granulomatous epulis.
由于局部刺激、体内激素水平或切除不完全，肉芽肿性牙龈瘤术后复发很常见。目前，如果复发，通常会拔除病变相邻的牙齿，这可能会影响美观或咀嚼功能。因此，迫切需要一种更有效且侵袭性更小的治疗方法，尤其是对于复发性病变。本研究调查了瘤内注射平阳霉素（PYM）治疗复发性肉芽肿性牙龈瘤的效果并评估了并发症。
2010年7月至2014年6月期间，共有16例复发性肉芽肿性牙龈瘤患者接受了瘤内PYM注射。对治疗效果和并发症进行了回顾性分析。
总共进行了48次注射（针对所有患者）。每位患者注射次数的中位数为3次（范围为2至4次）。所有病例在随访超过12个月后均完全康复，无复发且牙槽骨无吸收。并发症包括注射后轻微出血、局部肿胀和疼痛。所有这些症状在注射后7至10天内缓解。
总之，瘤内注射PYM可能是复发性肉芽肿性牙龈瘤的首选治疗方法。
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