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巴布亚新几内亚一家乡村医院儿童血源性骨髓炎的管理

Management of childhood haematogenous osteomyelitis in a rural Papua New Guinean hospital.

作者信息

Van Gurp G, Kila R, Hutchinson T

出版信息

P N G Med J. 1989 Jun;32(2):117-22.

PMID:2816072
Abstract

Haematogenous osteomyelitis, especially in its more common chronic stage, is an important cause of morbidity in children in the Southern Highlands Province. Hospital stays are lengthy and the incidence of fractures is high. While awaiting, or in the absence of, culture and sensitivity results, cloxacillin 200 mg/kg/day plus probenecid 40 mg/kg/day is an appropriate first choice antibiotic when it is available. Antibiotic therapy in chronic disease should be limited to the specific settings of associated soft tissue infection; pre- and post-sequestrectomy; and radiological signs of ongoing bone necrosis and systemic signs of active infection. Surgical drainage of subperiosteal pus and possibly the medullary canal is required in all but the very early (less than 48 hours) cases of acute osteomyelitis that sometimes respond to antibiotics alone. Sequestrectomy should be reserved for cases where a sequestrum and adequate involucrum can be seen on X-ray. Effective management of this disease is possible only if ongoing communication exists between hospital-based medical staff and the staff of health centres or subcentres, including the network of aid post orderlies and their supervisors. Since the majority of patients present to facilities other than hospitals, any campaign directed at improving management must involve co-workers in rural areas, namely the health extension officer, nurse and aid post orderly. Only in this way can we hope to achieve earlier appropriate treatment and more systematic long-term follow-up.

摘要

血源性骨髓炎,尤其是在其更常见的慢性阶段,是南部高地省儿童发病的一个重要原因。住院时间长,骨折发生率高。在等待培养和药敏结果或没有这些结果时,若有可用的氯唑西林,200毫克/千克/天加丙磺舒40毫克/千克/天是合适的首选抗生素。慢性病的抗生素治疗应限于相关软组织感染的特定情况;死骨切除术前后;以及持续骨坏死的放射学征象和活跃感染的全身征象。除了极少数非常早期(少于48小时)有时仅用抗生素治疗就有效的急性骨髓炎病例外,所有病例都需要对骨膜下脓肿甚至骨髓腔进行手术引流。死骨切除术应仅用于X线片上能看到死骨和足够骨壳的病例。只有当医院医务人员与保健中心或分中心的工作人员,包括急救站护理员及其主管网络之间保持持续沟通时,才有可能对这种疾病进行有效管理。由于大多数患者前往医院以外的机构就诊,任何旨在改善管理的活动都必须让农村地区的同事参与,即卫生推广官员、护士和急救站护理员。只有这样,我们才有希望实现更早的适当治疗和更系统的长期随访。

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