Noda Yoshihiro, Zomorrodi Reza, Saeki Takashi, Rajji Tarek K, Blumberger Daniel M, Daskalakis Zafiris J, Nakamura Motoaki
Laboratory of Neuromodulation, Kanagawa Psychiatric Center, Yokohama, Japan; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Clin Neurophysiol. 2017 Mar;128(3):424-432. doi: 10.1016/j.clinph.2016.12.023. Epub 2017 Jan 9.
We aimed to investigate neuromodulatory effects of high-frequency left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation (rTMS) on resting-state electroencephalography (EEG) and their clinical and cognitive correlates in patients with depression.
Thirty-one patients diagnosed with depression included in the present study. Resting-state gamma power and theta-gamma coupling (TGC) were calculated before and after a course of rTMS. We explored the relationship among gamma power, TGC, and clinical/cognitive outcomes as measured with the Hamilton Rating Scale for Depression (HAM-D), Beck Depression Inventory (BDI), and Wisconsin Card Sorting Test (WCST).
Following rTMS, depressed patients demonstrated significant increases of resting gamma power at the F3 and F4 electrode sites and resting TGC at the C3 and T3 electrode sites. Furthermore, the increased gamma power at the F3 electrode site was significantly correlated with improved score on the HAM-D and BDI, while the increased TGC at the C3 electrode site was significantly correlated with reduced number of errors on the WCST.
Thus, resting-state gamma power and TGC may represent potential biomarkers of depression associated with therapeutic effects of rTMS.
Resting-state EEG may provide potential biomarkers related to therapeutic effects of rTMS.
我们旨在研究高频左侧背外侧前额叶皮质重复经颅磁刺激（rTMS）对抑郁症患者静息态脑电图（EEG）的神经调节作用及其临床和认知相关性。
本研究纳入31例诊断为抑郁症的患者。在一个rTMS疗程前后计算静息态γ功率和θ-γ耦合（TGC）。我们探讨了γ功率、TGC与通过汉密尔顿抑郁量表（HAM-D）、贝克抑郁量表（BDI）和威斯康星卡片分类测验（WCST）测量的临床/认知结果之间的关系。
rTMS后，抑郁症患者在F3和F4电极部位的静息γ功率以及在C3和T3电极部位的静息TGC显著增加。此外，F3电极部位γ功率的增加与HAM-D和BDI评分的改善显著相关，而C3电极部位TGC的增加与WCST错误数量的减少显著相关。
因此，静息态γ功率和TGC可能代表与rTMS治疗效果相关的抑郁症潜在生物标志物。
静息态EEG可能提供与rTMS治疗效果相关的潜在生物标志物。
