Herati Amin S, Zhelyazkova Boryana H, Butler Peter R, Lamb Dolores J
Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Scott Department of Urology, Baylor College of Medicine, Houston, Texas.
Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas.
Fertil Steril. 2017 Feb;107(2):319-323. doi: 10.1016/j.fertnstert.2016.12.021.
Paternal aging is associated with increased risk of genetic disease transmission to the offspring. The changes associated with aging arise predominantly through formation of single nucleotide variation through DNA replication errors, as well as possibly chronic exposure to environmental toxins and reactive oxygen species exposure. Several age-related reproductive factors are also contributory, including the systemic hormonal milieu, accumulation of environmental toxin exposure, aging germ cells, and accumulation of de novo genetic and genomic abnormalities in germ cells. In this article we review the age-related genetic and genomic changes that occur in the male germ line.
父系衰老与向后代传播遗传疾病的风险增加有关。与衰老相关的变化主要通过DNA复制错误形成单核苷酸变异而产生，也可能是由于长期暴露于环境毒素和活性氧。一些与年龄相关的生殖因素也有影响，包括全身激素环境、环境毒素暴露的积累、生殖细胞衰老以及生殖细胞中新发遗传和基因组异常的积累。在本文中，我们综述了雄性生殖系中发生的与年龄相关的遗传和基因组变化。
