Fowler Leanne H, Lee Susan
School of Nursing, Louisiana State University Health Sciences Center, 1900 Gravier Street, New Orleans, LA 70112, USA.
School of Nursing, Louisiana State University Health Sciences Center, 1900 Gravier Street, New Orleans, LA 70112, USA.
Crit Care Nurs Clin North Am. 2017 Mar;29(1):111-118. doi: 10.1016/j.cnc.2016.09.010. Epub 2016 Nov 15.
Isolates from ICUs most commonly find multidrug-resistant (MDR) gram-negative bacteria. The purpose of this article is to discuss the significant impact MDR gram-negative infections are having on ICUs, the threat on health and mortality, and effective and new approaches aimed to combat MDR gram-negative infections in critically ill populations. Inappropriate antibiotic therapies for suspected or documented infections are the leading cause of the emergence of bacterial resistance. A variety of strategies are aimed at combatting this international burden via antibiotic stewardship programs. Studies are demonstrating promise against the virulence MDR gram-negative infections have posed.
重症监护病房（ICU）分离出的菌株中最常见的是多重耐药（MDR）革兰氏阴性菌。本文旨在探讨多重耐药革兰氏阴性菌感染对重症监护病房的重大影响、对健康和死亡率的威胁，以及针对重症患者对抗多重耐药革兰氏阴性菌感染的有效和新方法。对疑似或确诊感染进行不恰当的抗生素治疗是细菌耐药性出现的主要原因。通过抗生素管理计划，有多种策略旨在应对这一全球性负担。研究表明在对抗多重耐药革兰氏阴性菌感染所造成的致病性方面取得了成效。
