Martin Jennifer B, Badeaux Jennifer E
Nurse Anesthesia Program, School of Nursing, Louisiana State University Health Sciences Center, 1900 Gravier Street, New Orleans, LA 70112, USA.
Nurse Anesthesia Program, School of Nursing, Louisiana State University Health Sciences Center, 1900 Gravier Street, New Orleans, LA 70112, USA.
Crit Care Nurs Clin North Am. 2017 Mar;29(1):119-130. doi: 10.1016/j.cnc.2016.09.004. Epub 2016 Dec 14.
Sepsis and severe sepsis are leading causes of death in the United States and the most common causes of death among critically ill patients in noncoronary intensive care units. Diagnosis of infection and sepsis is a subjective clinical judgment based on the criteria for systemic inflammatory reaction, which is highly sensitive, not specific, and often misleading in intensively treated patients. Biomarkers are emerging as adjuncts to traditional diagnostic measures. No biomarkers have sufficient specificity or sensitivity to be routinely used in clinical practice, but they can aid in the diagnosis and treatment of infection versus inflammation.
脓毒症和严重脓毒症是美国的主要死因，也是非冠心病重症监护病房中重症患者最常见的死因。感染和脓毒症的诊断是基于全身炎症反应标准的主观临床判断，该标准高度敏感但不具特异性，在接受强化治疗的患者中常常具有误导性。生物标志物正逐渐成为传统诊断方法的辅助手段。目前尚无生物标志物具有足够的特异性或敏感性可常规用于临床实践，但它们有助于区分感染与炎症，以指导诊断和治疗。
