Deplanque X, Wullens A, Norberciak L
Service de médecine polyvalente, hôpital Saint-Vincent de-Paul, GHICL, boulevard de Belfort, BP 387, 59020 Lille cedex, France.
Service de médecine polyvalente, hôpital Saint-Vincent de-Paul, GHICL, boulevard de Belfort, BP 387, 59020 Lille cedex, France.
Rev Med Interne. 2017 Jun;38(6):368-373. doi: 10.1016/j.revmed.2016.12.013. Epub 2017 Feb 1.
Screening and treatment of vitamin D deficiency are the subject of several publications. A lot of recognized risk factors have increased steadily, leading to the recognition of populations at risk. Despite their exposure to the same risk factors as other populations, there are no recommendations concerning healthy adults, a population rarely studied. To determine the prevalence of vitamin D deficiency in healthy adults aged 18-65 years residing in northern France and to search for correlated risk factors at 20ng/mL.
Descriptive, prospective, single-center epidemiology study; 297 subjects studied in January and February, 2015. The prevalence of vitamin D deficiency was determined at three serum levels (10, 20 and 30ng/mL). A self-administered questionnaire was used to identify risk factors correlated with vitamin D deficiency (<20ng/mL).
25(OH) vitamin D serum level was strictly less than 30ng/mL in 92.3% of participants, strictly less than 20ng/mL in 75.1%, and strictly less than 10ng/mL in 27.9%. Male gender (P=0.0001), age (P=0.012), no vacations in sunny regions (P=0.03) and no intake of prescription vitamin supplements (P=0.002) were independent risk factors of vitamin D deficiency (<20ng/mL).
In our population, vitamin D deficiency is frequent in healthy adults and is often severe. A systematic screening and supplementation strategy would limit the development of many pathological complications and ensure good nutritional balance.
维生素D缺乏症的筛查与治疗是多篇出版物的主题。许多公认的风险因素稳步增加，导致了对高危人群的识别。尽管健康成年人与其他人群面临相同的风险因素，但针对这一鲜有研究的人群却没有相关建议。本研究旨在确定居住在法国北部的18 - 65岁健康成年人中维生素D缺乏症的患病率，并寻找与血清20ng/mL水平相关的风险因素。
描述性、前瞻性、单中心流行病学研究；2015年1月和2月对297名受试者进行研究。在三个血清水平（10、20和30ng/mL）测定维生素D缺乏症的患病率。使用一份自行填写的问卷来识别与维生素D缺乏（<20ng/mL）相关的风险因素。
92.3%的参与者血清25(OH)维生素D水平严格低于30ng/mL，75.1%严格低于20ng/mL，27.9%严格低于10ng/mL。男性（P = 0.0001）、年龄（P = 0.012）、未在阳光充足地区度假（P = 0.03）以及未摄入处方维生素补充剂（P = 0.002）是维生素D缺乏（<20ng/mL）的独立风险因素。
在我们的研究人群中，健康成年人中维生素D缺乏症很常见，且往往较为严重。系统的筛查和补充策略将限制许多病理并发症的发生，并确保良好的营养平衡。
