Charilaou Paris, Agnihotri Kanishk, Garcia Pablo, Badheka Apurva, Frenia Douglas, Yegneswaran Balaji
Department of Internal Medicine, Rutgers/Saint Peter's University Hospital, New Brunswick, NJ.
Department of Internal Medicine, Rutgers/Saint Peter's University Hospital, New Brunswick, NJ.
Am J Med. 2017 Jun;130(6):678-687.e7. doi: 10.1016/j.amjmed.2016.12.035. Epub 2017 Feb 2.
The nationwide prevalence of cannabis use/abuse has more than doubled from 2002 to 2011. Whether the outpatient trend is reflected in the inpatient setting is unknown. We examined the prevalence and incidence of cannabis abuse/dependence as determined by discharge coding in a 10-year (2002-2011) National Inpatient Sample, as well as various trends among demographics, comorbidities, and hospitalization outcomes.
Cannabis abuse/dependence was identified on the basis of International Classification of Diseases, 9th Revision, Clinical Modification codes 304.3* and 305.2* in adults aged 18 years or more. We excluded cases coded "in remission." National estimates of trends and matched-regression analyses were conducted.
Overall, 2,833,567 (0.91%) admissions with documented cannabis abuse/dependence were identified, patients had a mean age of 35.12 ± 0.06 years, 62% were male, and there was an increasing trend in prevalence from 0.52% to 1.34% (P <.001). The mean Charlson Comorbidity Index was 0.47 ± 0.006, and inpatient mortality was 0.41%. All of the above demonstrated an increasing trend (P <.001). Mean length of stay was 6.23 ± 0.06 days. The top primary discharge diagnoses were schizoaffective/mood disorders, followed by psychotic disorders and alcoholism. Asthma prevalence in nontobacco smokers had a steeper increase in the cannabis subgroup than in the noncannabis subgroup (P = .002). Among acute pancreatitis admissions, cannabis abusers had a shorter length of stay (-11%) and lower hospitalization costs (-7%) than nonabusers.
Cannabis abuse/dependence is on the rise in the inpatient population, with an increasing trend toward older and sicker patients with increasing rates of moderate to severe disability. Psychiatric disorders and alcoholism are the main associated primary conditions. Cannabis abuse is associated with increased asthma incidence in nontobacco smokers and decreased hospital resource use in acute pancreatitis admissions.
2002年至2011年期间,全国范围内大麻使用/滥用的流行率增加了一倍多。门诊趋势是否反映在住院患者中尚不清楚。我们通过对10年(2002 - 2011年)全国住院患者样本中的出院编码来检查大麻滥用/依赖的患病率和发病率,以及人口统计学、合并症和住院结局的各种趋势。
根据《国际疾病分类》第9版临床修订本代码304.3和305.2确定18岁及以上成年人中的大麻滥用/依赖情况。我们排除了编码为“缓解期”的病例。进行了全国趋势估计和匹配回归分析。
总体而言,共识别出2,833,567例(0.91%)有记录的大麻滥用/依赖住院病例,患者平均年龄为35.12±0.06岁,62%为男性,患病率从0.52%上升至1.34%(P<.001),呈上升趋势。平均查尔森合并症指数为0.47±0.006,住院死亡率为0.41%。以上所有均呈上升趋势(P<.001)。平均住院时间为6.23±0.06天。首要出院诊断主要是分裂情感性/情绪障碍,其次是精神障碍和酒精中毒。非吸烟者中,大麻亚组的哮喘患病率比非大麻亚组上升幅度更大(P = 0.002)。在急性胰腺炎住院病例中,大麻滥用者的住院时间较短(-11%),住院费用较低(-7%)。
住院患者中大麻滥用/依赖呈上升趋势,患者年龄越来越大、病情越来越重,中度至重度残疾率也在上升。精神障碍和酒精中毒是主要的相关原发疾病。大麻滥用与非吸烟者哮喘发病率增加以及急性胰腺炎住院病例中医院资源使用减少有关。