Karki Niraj, Sapkota Binita, Magar Swosti R, Muhammad Ameen, Paudel Bishow M, Chernek Peter, Afshar Maryam, Bhandari Manoj, Bella Jonathan N
Internal Medicine, Catholic Health Initiatives (CHI) St. Vincent, Little Rock, USA.
Rheumatology/Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, USA.
Cureus. 2022 Mar 19;14(3):e23317. doi: 10.7759/cureus.23317. eCollection 2022 Mar.
Recreational marijuana use is rising, especially among young adults. The cardiovascular (CVD) effect of marijuana remains mostly unknown.
This is a retrospective study of 14,490 patients admitted to our hospital between 2012 and 2014 who had urine toxicology done for various reasons. Patients with a primary diagnosis of acute coronary syndrome (ACS) were queried in both the marijuana-positive group (n = 59) and the marijuana-negative group (n = 195). The risks of having ACS were compared in both groups.
There was no difference in the risk of having ACS between the two groups in the population < 54 years of age (OR: 0.90, 95% CI: 0.67-1.20, p = 0.48). However, there was a significant difference in the risk of having ACS in the 18-36 age group (OR: 2.84, 95% CI: 1.14-7.07, p = 0.01). Multivariate analysis performed to adjust for the potential confounding effects of smoking and cocaine use showed that marijuana use (OR: 0.93, 95% CI: 0.68-1.25, p = 0.65) did not increase the likelihood of ACS for patients ≤ 54 years or for those in the 37-54 age group (OR: 1.11, 95% CI: 0.79-1.53, p = 0.50). However, among the 18-36 age bracket, marijuana use was independently associated with a higher risk of ACS (OR: 5.24, 95% CI: 1.84-16.93, p = 0.002).
In younger patients (age 18-36 years), marijuana use is independently associated with a five-fold higher risk of ACS.
娱乐性大麻使用呈上升趋势，尤其是在年轻人中。大麻对心血管（CVD）的影响大多仍不明确。
这是一项对2012年至2014年间因各种原因入院且进行了尿液毒理学检测的14490名患者的回顾性研究。在大麻阳性组（n = 59）和大麻阴性组（n = 195）中对急性冠状动脉综合征（ACS）原发性诊断患者进行询问。比较两组发生ACS的风险。
在年龄小于54岁的人群中，两组发生ACS的风险无差异（OR：0.90，95% CI：0.67 - 1.20，p = 0.48）。然而，在18 - 36岁年龄组中，发生ACS的风险存在显著差异（OR：2.84，95% CI：1.14 - 7.07，p = 0.01）。为调整吸烟和使用可卡因的潜在混杂效应而进行的多变量分析显示，对于年龄≤54岁的患者或37 - 54岁年龄组的患者，使用大麻（OR：0.93，95% CI：0.68 - 1.25，p = 0.65）并未增加发生ACS的可能性。然而，在18 - 36岁年龄组中，使用大麻与发生ACS的较高风险独立相关（OR：5.24，95% CI：1.84 - 16.93，p = 0.002）。
在年轻患者（18 - 36岁）中，使用大麻与发生ACS的风险高出五倍独立相关。
