Aleksevich Ia I
Biull Eksp Biol Med. 1978;86(7):40-2.
Experiments were conducted on rabbits with tetanus intoxication induced by the intravenous injection of a lethal dose of the toxin; a study was made of the therapeutic efficacy of the acetylcholinesterase reactivators--dipyroxim and isonitrosine, and also of the central cholinolytics--amizyl and diphacyl. In dose of 25 mg/kg dipyroxim produced no therapeutic effect, and in doses of 30--40 mg/kg caused the animal death. Amizyl and diphacil in a dose of 3--4 mg/kg caused elimination of tonic convulsions for 1 1/2--2 hours. As to isonitrosin--it produced the same effect for 4--5 hours. In case of combined administration of reactivators and cholinolytics convulsions were eliminated for 4--5 hours.
对静脉注射致死剂量毒素诱导破伤风中毒的家兔进行了实验；研究了乙酰胆碱酯酶复活剂——双吡啶肟和异硝基酪氨酸以及中枢抗胆碱药——阿米齐尔和地法酰的治疗效果。双吡啶肟剂量为25mg/kg时未产生治疗效果，剂量为30 - 40mg/kg时导致动物死亡。阿米齐尔和地法酰剂量为3 - 4mg/kg时可使强直性惊厥消失1.5 - 2小时。而异硝基酪氨酸——可使强直性惊厥消失4 - 5小时。复活剂与抗胆碱药联合使用时，惊厥可消失4 - 5小时。
