Kokshareva N V, Kovtun S D, Kagan Iu S, Miziukova I G, Medvedev B M
Biull Eksp Biol Med. 1977 Jan;83(1):29-32.
A new cholinesteras reactivator--chlorohydrate of S-diethylaminoethyl ether p-bromo benzoylthiohydroxime acid (diethixime), containing a tertiary nitrogen atom in the molecule, was shown to produce a central effect in a dose of 20 mg/kg--1/50 LD50--in contrast to diproxime in a dose of 3 mg/kg, containing a quarternary nitrogen atom, under intoxication of albino rats and rabbits with dimethyl-dichlorynylphosphate. This effect was confirmed by the restortion of the cholinesterase activity in different parts of the rabbit brain, by the normalization of the EEGand of the functional stateof motor neurons of the rat spinal cord.
一种新的胆碱酯酶复活剂——S - 二乙氨基乙基醚对溴苯甲酰硫代羟肟酸氯酸盐（双复磷），其分子中含有叔氮原子，结果表明，在白化大鼠和家兔被二甲基二氯戊烯基磷酸酯中毒的情况下，该复活剂以20毫克/千克的剂量（半数致死量的1/50）可产生中枢效应，这与含有季氮原子的双磷酰硫胆碱以3毫克/千克的剂量所产生的效应形成对比。兔脑不同部位胆碱酯酶活性的恢复、脑电图的正常化以及大鼠脊髓运动神经元功能状态的恢复均证实了这一效应。
