Klit Anders, Tvedskov Tove Filtenborg, Kroman Niels, Elberg Jens Jørgen, Ejlertsen Bent, Henriksen Trine Foged
a Department of Plastic Surgery, Breast Surgery and Burns Treatment , Rigshospitalet, Copenhagen University Hospital , Copenhagen , Denmark.
b Danish Breast Cancer Group , The Danish Cancer Society , Copenhagen , Denmark.
Acta Oncol. 2017 May;56(5):719-723. doi: 10.1080/0284186X.2017.1281437. Epub 2017 Feb 6.
Only a few studies of limited size have examined whether oncoplastic breast surgery delays the onset of adjuvant chemotherapy as compared to conventional breast surgery. We investigated whether oncoplastic breast surgery causes a delay in the onset of adjuvant chemotherapy in comparison to lumpectomy and mastectomy.
The study is a population-based cohort study. Within the nationwide registry of the Danish Breast Cancer Group (DBCG), we identified 1798 patients who received adjuvant chemotherapy following mastectomy, lumpectomy or oncoplastic breast surgery for early and unilateral invasive breast cancer. Women treated with neoadjuvant chemotherapy were excluded.
We found no significant difference between the three groups (mastectomy, lumpectomy, oncoplastic breast surgery) in the time from biopsy to surgery (mean time 17.9, 17.0 and 18.3 days, respectively), the time from surgery to onset of adjuvant chemotherapy, nor total time from biopsy to the onset of adjuvant chemotherapy (mean time 52.7, 51.9 and 53.2 days, respectively).
Our study shows that oncoplastic breast surgery does not delay the onset of adjuvant chemotherapy in comparison with mastectomy and lumpectomy. Accordingly, patients should not be excluded from treatment with oncoplastic breast surgery due to concerns of delay in adjuvant chemotherapy.
仅有少数规模有限的研究探讨了与传统乳房手术相比，肿瘤整形乳房手术是否会延迟辅助化疗的开始时间。我们调查了与乳房肿块切除术和乳房切除术相比，肿瘤整形乳房手术是否会导致辅助化疗开始时间的延迟。
本研究是一项基于人群的队列研究。在丹麦乳腺癌组（DBCG）的全国性登记处中，我们确定了1798例因早期单侧浸润性乳腺癌接受乳房切除术、乳房肿块切除术或肿瘤整形乳房手术后接受辅助化疗的患者。接受新辅助化疗的女性被排除在外。
我们发现三组（乳房切除术、乳房肿块切除术、肿瘤整形乳房手术）在从活检到手术的时间（平均时间分别为17.9、17.0和18.3天）、从手术到辅助化疗开始的时间以及从活检到辅助化疗开始的总时间（平均时间分别为52.7、51.9和53.2天）方面均无显著差异。
我们的研究表明，与乳房切除术和乳房肿块切除术相比，肿瘤整形乳房手术不会延迟辅助化疗的开始时间。因此，不应因担心辅助化疗延迟而将患者排除在肿瘤整形乳房手术治疗之外。
