Alam Md Shahid, Praveen Kumar K V
Department of Orbit Oculoplasty Reconstructive and Aesthetic Services, Sankara Nethralaya Medical Research Foundation, Chennai, Tamil Nadu, India.
Department of Ophthalmology, Narayana Medical College, Nellore, Andhra Pradesh, India.
J Pharmacol Pharmacother. 2016 Oct-Dec;7(4):184-186. doi: 10.4103/0976-500X.195904.
A variety of systemic drugs including corticosteroids, amiodarone and antipsychotics have been known to cause cataract formation. Typical antipsychotics such as chlorpromazine have been reported to cause cataract formation in varying rates ranging from 22% to 80%. Cataract as an adverse effect resulting from the long term use of atypical antipsychotic has rarely been mentioned in literature, and there is only a single case report of cataract formation from prolonged use of clozapine. We report a rare case of clozpine induced cataract in a young female. The patient was advised to consult her psychiatrist for a change of drug and to undergo cataract surgery.
包括皮质类固醇、胺碘酮和抗精神病药物在内的多种全身性药物已知会导致白内障形成。据报道,典型的抗精神病药物如氯丙嗪导致白内障形成的发生率各不相同,范围从22%到80%。作为长期使用非典型抗精神病药物产生的不良反应,白内障在文献中很少被提及,仅有一例关于长期使用氯氮平导致白内障形成的病例报告。我们报告了一例年轻女性因氯氮平诱发白内障的罕见病例。建议该患者咨询精神科医生以更换药物,并接受白内障手术。