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坦桑尼亚米松圭区传统眼药的民族医学调查与安全性评估

Ethnomedical survey and safety evaluation of traditional eye medicines used in Misungwi district, Tanzania.

作者信息

Maregesi Sheila M, Messo Charles W, Mathias Juma

机构信息

Department of Pharmacognosy, Muhimbili University of Health and Allied Sciences, University of Dar es Salaam, Dar es Salaam, Tanzania.

出版信息

J Intercult Ethnopharmacol. 2016 Nov 21;6(1):75-83. doi: 10.5455/jice.20161116071244. eCollection 2017 Jan-Mar.

Abstract

AIM

This study aimed at documenting products used as traditional eye medicine (TEM) in Misungwi district, Tanzania, and performing preliminary analysis on safety status.

METHODOLOGY

Ethnomedical study was conducted in Misungwi district. Information was sourced by face-to-face interview with traditional healers, traditional medicine vendors, and knowledgeable people guided by a well-structured questionnaire. Safety was evaluated by determining pH using pH meter and mineral analysis using the Delta, Portable X-ray fluorescence equipment, and qualitative chemical tests.

RESULTS

A total of 23 TEM products were recorded from botanical (79%) and zoological (21%) sources including animal excreta. Liquid preparation ranked highest among dosage forms. Safety evaluation showed that only one product possessed the pH value of 7.4 as recommended for topical ophthalmic medicines. Fourteen minerals were detected and quantified in three samples; some of these minerals are known for their negative effects to the eyes, of medical interest is strontium used for the management of benign eye tumors. Information providers were unaware of health risks associated with the use of TEM.

CONCLUSION

This study has revealed the common use of TEM in Misungwi district. The majority of the products are from the botanical source. Although literature provides supporting data for the application to some of the recorded TEM, safety evaluation by pH and mineral analysis in this study have indicated possible ophthalmological medical problems that could result from using such products. Extensive scientific studies including animal experiments and identification of bioactive compounds are essential to develop safe TEMs.

摘要

目的

本研究旨在记录坦桑尼亚米松圭区用作传统眼药(TEM)的产品,并对其安全状况进行初步分析。

方法

在米松圭区开展民族医学研究。通过使用结构良好的问卷,与传统治疗师、传统药品供应商和知情人士进行面对面访谈来获取信息。通过使用pH计测定pH值以及使用德尔塔便携式X射线荧光设备和定性化学测试进行矿物分析来评估安全性。

结果

共记录了23种来自植物(79%)和动物(21%)来源(包括动物排泄物)的传统眼药产品。液体制剂在剂型中占比最高。安全性评估表明,只有一种产品的pH值符合局部眼科用药推荐的7.4。在三个样本中检测并定量了14种矿物质;其中一些矿物质已知对眼睛有负面影响,具有医学意义的是用于治疗良性眼肿瘤的锶。信息提供者未意识到使用传统眼药相关的健康风险。

结论

本研究揭示了米松圭区传统眼药的普遍使用情况。大多数产品来自植物来源。尽管文献为部分记录的传统眼药的应用提供了支持数据,但本研究通过pH值和矿物分析进行的安全性评估表明,使用此类产品可能会导致眼科医学问题。开展包括动物实验和生物活性化合物鉴定在内的广泛科学研究对于开发安全的传统眼药至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59a/5289092/7b84faac171f/JIE-6-75-g001.jpg

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