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乳腺癌的“大数据”:何处探寻及你将发现什么。

"Big Data" for Breast Cancer: Where to look and what you will find.

作者信息

Clare Susan E, Shaw Pamela L

机构信息

Department of Surgery, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Lurie 4-113, Chicago, IL 60611.

Biosciences & Bioinformatics Librarian, NIH Public Access Compliance Reporter (PACR), Galter Health Sciences Library, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave., Room 1-285, Chicago, IL 60611.

出版信息

NPJ Breast Cancer. 2016;2:16031-. doi: 10.1038/npjbcancer.2016.31. Epub 2016 Nov 2.

Abstract

Accessing the massive amount of breast cancer data that is currently publically available may seem daunting to the brand new graduate student embarking on his/her first project or even to the seasoned lab leader, who may wish to explore a new avenue of investigation. In this review, we provide an overview of data resources focusing on high-throughput data and on cancer-related data resources. While not intended as an exhaustive list, the information included in this review will provide a jumping off point with descriptions of and links to the various data resources of interest. The review is divided into six sections: (1) Compendia of data resources; (2) Biomolecular Repository "Hubs"' (3) A list of cancer-related data resources, which provides information on contents of the resource and whether the resource enables upload and analysis of investigator provided data; (4) A list of seminal publications containing specific breast cancer data, e.g., publications from METBRIC, Sanger, TCGA; (5) A list of journals focused on data science that include cancer-related "Big Data"; and (6) Miscellaneous resources.

摘要

对于刚开始着手第一个项目的新研究生,甚至对于可能希望探索新研究途径的经验丰富的实验室负责人来说,获取目前公开可用的大量乳腺癌数据似乎令人生畏。在本综述中,我们概述了专注于高通量数据和癌症相关数据资源的数据资源。虽然本综述并非旨在列出详尽的清单,但其中包含的信息将提供一个起点,介绍各种相关数据资源并提供指向它们的链接。本综述分为六个部分:(1)数据资源汇编;(2)生物分子储存库“中心”;(3)癌症相关数据资源列表,其中提供了有关资源内容的信息以及该资源是否允许上传和分析研究人员提供的数据;(4)包含特定乳腺癌数据的重要出版物列表,例如来自METBRIC、桑格研究所、癌症基因组图谱(TCGA)的出版物;(5)专注于数据科学且包含癌症相关“大数据”的期刊列表;以及(6)其他资源。

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