ST段抬高型心肌梗死患者的血清Salusin水平

Serum Salusin Levels in ST-Segment Elevation Myocardial Infarction.

作者信息

Yilmaz Mustafa, Atescelik Metin, Ardic Sukru, Goktekin Mehmet C, Yildiz Mustafa, Gurger Mehtap, Kobat Mehmet A, Ilhan Nevin

出版信息

Clin Lab. 2016 Sep 1;62(9):1717-1723. doi: 10.7754/Clin.Lab.2016.160136.

DOI:10.7754/Clin.Lab.2016.160136

PMID:28164579

Abstract

BACKGROUND

In our study, we aimed to determine the change in levels of salusin-alpha and salusin-beta at admission and after the treatment in patients with STEMI, who have active atherosclerosis.

METHODS

Serum salusin-alpha and beta levels of 50 patients diagnosed with STEMI in the emergency department were measured at admission and on 7th day post-treatment and compared with serum salusin levels of 50 healthy volunteers.

RESULTS

In STEMI patients, salusin-alpha levels were found to be significantly decreased (p < 0.001) and salusinbeta levels were found to be significantly increased (p < 0.001) compared to healthy volunteers in the control group. 7th day post-treatment salusin-alpha levels were found to be lower and salusin-beta levels were found to be at a higher level compared to healthy individuals (p < 0.001). Negative correlation (r = -.322 p = 0.023) was found between salusin-alpha levels and pulse rate. But no significant correlation was found between salusin-beta levels and biochemical parameters.

CONCLUSIONS

The data of this study support the fact that salusin-alpha levels decrease and salusin-beta levels increase in acute cases such as STEMI.

摘要

背景

在我们的研究中，我们旨在确定患有活动性动脉粥样硬化的ST段抬高型心肌梗死（STEMI）患者入院时及治疗后的salusin-α和salusin-β水平变化。

方法

对急诊科确诊为STEMI的50例患者在入院时及治疗后第7天测量血清salusin-α和β水平，并与50名健康志愿者的血清salusin水平进行比较。

结果

与对照组健康志愿者相比，STEMI患者的salusin-α水平显著降低（p<0.001），salusin-β水平显著升高（p<0.001）。治疗后第7天，与健康个体相比，salusin-α水平较低，salusin-β水平较高（p<0.001）。salusin-α水平与脉搏率之间存在负相关（r = -0.322，p = 0.023）。但salusin-β水平与生化参数之间未发现显著相关性。