Akyüz Aydın, Aydın Fatma, Alpsoy Şeref, Ozkaramanli Gur Demet, Guzel Savas
Department of Cardiology, Faculty of Medicine, Namık Kemal University; Tekirdağ-Turkey.
Department of Cardiovascular Physiology, Institute of Health Sciences, Faculty of Medicine, Namık Kemal University; Tekirdağ-Turkey.
Anatol J Cardiol. 2019 Sep;22(4):177-184. doi: 10.14744/AnatolJCardiol.2019.43247.
The pathophysiology of coronary slow flow (CSF) has not been clarified. Salusin-β is released predominantly from the atheroma plaques and influences the pathophysiologic processes of atherosclerosis. Therefore, this study aimed to determine serum salusin-β levels in CSF and its correlation with CSF.
The study included 39 patients with CSF, and the control group (n=42) consisted of consecutive subjects with normal coronary arteriogram. We measured salusin-β and thrombolysis in myocardial infarction frame count (TFC).
Age, body mass index (BMI), systolic blood pressure, diabetes, hyperlipidemia, and smoking rates were similar (p values>0.05) in both groups. High sensitive C-reactive protein (2.80±1.2 vs. 2.21±1.2 mg/dL, p=0.011), salusin-β [1205 (330-2092) vs. 162 (29-676), pg/ml, p<0.001], corrected TFC of left anterior descending coronary artery (29±9 vs. 19.7±3.7, p<0.001), circumflex artery TFC (25±10 vs. 15±3.2, p<0.001), right coronary artery TFC (28±7.1 vs. 13±3.3, p<0.001), and mean TFC (28±4.4 vs. 16±3.7, p<0.001) were significantly higher in the CSF group. In univariate and multivariate regression analysis, only BMI (unstandardized β±SE=0.178±0.08, p=0.036) and salusin-β levels (unstandardized β±SE=0.006±0.01, p<0.001) were determined as predictors of CSF. There was a good correlation between serum salusin-β and mean TFC values (r=0.564; p<0.001).
There is an association between serum salusin-β levels and CSF.
冠状动脉慢血流（CSF）的病理生理学尚未阐明。Salusin-β主要从动脉粥样硬化斑块中释放出来，并影响动脉粥样硬化的病理生理过程。因此，本研究旨在测定CSF患者的血清Salusin-β水平及其与CSF的相关性。
本研究纳入39例CSF患者，对照组（n=42）由冠状动脉造影正常的连续受试者组成。我们测量了Salusin-β和心肌梗死溶栓帧数（TFC）。
两组患者的年龄、体重指数（BMI）、收缩压、糖尿病、高脂血症和吸烟率相似（p值>0.05）。CSF组的高敏C反应蛋白（2.80±1.2 vs. 2.21±1.2 mg/dL，p=0.011）、Salusin-β[1205（330-2092）vs. 162（29-676），pg/ml，p<0.001]、左前降支冠状动脉校正TFC（29±9 vs. 19.7±3.7，p<0.001）、回旋支动脉TFC（25±10 vs. 15±3.2，p<0.001）、右冠状动脉TFC（28±7.1 vs. 13±3.3，p<0.001）和平均TFC（28±4.4 vs. 16±3.7，p<0.001）均显著更高。在单因素和多因素回归分析中，仅BMI（未标准化β±SE=0.178±0.08，p=0.036）和Salusin-β水平（未标准化β±SE=0.006±0.01，p<0.001）被确定为CSF的预测因素。血清Salusin-β与平均TFC值之间存在良好的相关性（r=0.564；p<0.001）。
血清Salusin-β水平与CSF之间存在关联。
