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[抗酸剂组化合物储存期间的相互作用研究。I. 混悬剂中各成分的相互作用]

[Study on the interactions during storage of compounds of the antacid group. I. Interactions of the components in suspensions].

作者信息

Pawlaczyk J, Lutka A

出版信息

Acta Pol Pharm. 1989;46(1):74-80.

PMID:2816464
Abstract

Twenty antacid mixtures of six quality groups containing Al(OH)3, gel, Mg(OH)2, Mg2Si3O8, CaCO3 and NaAl(OH)2CO3 at different ratios were prepared and stored for 150 days at 20 degrees C in the form of aqueous suspensions. Changes of pH in the suspensions were measured, and the accompanying structural changes were examined by IR spectrometry and X-ray diffraction analysis. Hydrotalcite was found to be formed during storage of aqueous suspensions of mixtures of Al(OH)3 Mg(OH)2; Al(OH)3: Mg(OH)2: CaCO3; Al(OH)3: Mg(OH)2: NaAl(OH)2CO3 and Mg(OH)2: NaAl(OH)2CO3. Initial neutralization activities of the suspensions and those found after the storage were compared.

摘要

制备了20种含有不同比例氢氧化铝、凝胶、氢氧化镁、硅酸镁、碳酸钙和碱式碳酸铝钠的六种质量组的抗酸混合物,并以水悬浮液的形式在20℃下储存150天。测量了悬浮液中pH值的变化,并通过红外光谱和X射线衍射分析检查了伴随的结构变化。发现在氢氧化铝-氢氧化镁混合物、氢氧化铝:氢氧化镁:碳酸钙、氢氧化铝:氢氧化镁:碱式碳酸铝钠和氢氧化镁:碱式碳酸铝钠的水悬浮液储存期间会形成水滑石。比较了悬浮液的初始中和活性和储存后测得的中和活性。

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