Chopra N K, Pande R S
Indian J Dermatol Venereol Leprol. 1985 May-Jun;51(3):144-147.
Renal involvement in 20 lepromatous leprosy (LL) and 5 non- lepromatous patients was assessed by (a) biochemical analysis of blood and urine, (b) renal functional tests, and (c) histopathological examination of renal biopsies. Ten age-matched healthy normals formed the control group. LL patients had a varying degree of renal involvement as indicated by the presence of pus cells, granular, hyaline and red cell casts, reversal of albumin/globulin ratio and lowered creatinine clearance rates. Renal biopsies showed significant histopathological lesions in 50% of lepromatous as compared to 20% of the non-lepromatous patients. The pathological changes were predominantly of chronic glomerulonephritis followed by chronic pyelonephritis and interstitial nephritis. Surprisingly none of the patients studied showed granulomas, acid-fast bacilli or amyloid in the kidney.
通过以下方式评估了20例瘤型麻风（LL）患者和5例非瘤型患者的肾脏受累情况：（a）血液和尿液的生化分析；（b）肾功能测试；（c）肾活检的组织病理学检查。选取10名年龄匹配的健康正常人作为对照组。LL患者存在不同程度的肾脏受累，表现为出现脓细胞、颗粒管型、透明管型和红细胞管型，白蛋白/球蛋白比例倒置以及肌酐清除率降低。肾活检显示，50%的瘤型患者有显著的组织病理学病变，而非瘤型患者的这一比例为20%。病理变化主要为慢性肾小球肾炎，其次是慢性肾盂肾炎和间质性肾炎。令人惊讶的是，所研究的患者中没有一人在肾脏中出现肉芽肿、抗酸杆菌或淀粉样物质。
