Ozturk Savas, Ozturk Tulin, Can Ilkay
Department of Dermatology, Medical Faculty, Balikesir University, Balikesir, Turkey.
Department of Radiology, Ataturk State Hospital, Balikesir, Turkey.
Postepy Dermatol Alergol. 2017 Jun;34(3):240-244. doi: 10.5114/ada.2017.67846. Epub 2017 May 29.
Renal involvement in leprosy has previously been described in the literature and can include amyloidosis, glomerulonephritis, nephrosclerosis, tubulointerstitial nephritis, and granulomas.
To evaluate renal involvement in Turkish patients with leprosy.
In total, 32 patients with lepromatous leprosy but without any co-morbidities and 35 healthy control subjects were evaluated for renal involvement at the Elazig Training and Research Hospital in Turkey. The laboratory tests and radiological results concerning renal function were taken from both the patients' medical records and from current examinations.
The levels of creatinine, urea, and leukocyturia in the lepromatous leprosy patients were significantly higher than in the controls ( < 0.001, < 0.001; = 0.001, < 0.01; = 0.036, < 0.05, respectively). No significant differences in the proteinuria, hematuria, sodium, or potassium levels were found between the leprosy and control groups ( > 0.05). On ultrasonographic examination, the prevalence of renal cortical cysts and renal cortical echogenicity in the leprosy patients was significantly higher than in the controls ( = 0.020, < 0.05, respectively). There were no significant differences in terms of nephrolithiasis, parapelvic cysts, or hydronephrosis between the leprosy and control groups ( > 0.05).
Evaluating the renal function in all leprosy patients is important to detect abnormalities and to prevent renal failure, which remains a potential cause of death in this disease.
麻风病的肾脏受累情况此前已有文献报道，可包括淀粉样变性、肾小球肾炎、肾硬化、肾小管间质性肾炎和肉芽肿。
评估土耳其麻风病患者的肾脏受累情况。
在土耳其埃拉泽培训与研究医院，对32例无任何合并症的瘤型麻风病患者和35名健康对照者进行了肾脏受累情况评估。有关肾功能的实验室检查和影像学结果取自患者的病历及当前检查。
瘤型麻风病患者的肌酐、尿素和白细胞尿水平显著高于对照组（分别为P<0.001，P<0.001；P = 0.001，P<0.01；P = 0.036，P<0.05）。麻风病组与对照组在蛋白尿、血尿、钠或钾水平上未发现显著差异（P>0.05）。超声检查显示，麻风病患者肾皮质囊肿的患病率和肾皮质回声显著高于对照组（分别为P = 0.020，P<0.05）。麻风病组与对照组在肾结石、肾盂旁囊肿或肾积水方面无显著差异（P>0.05）。
评估所有麻风病患者的肾功能对于发现异常和预防肾衰竭很重要，肾衰竭仍是该疾病潜在的死亡原因。
