Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
Chem Soc Rev. 2017 Feb 20;46(4):1193-1239. doi: 10.1039/c6cs00748a.
The focus of this review is on the class of transiently thermoresponsive polymers. These polymers are thermoresponsive, but gradually lose this property upon chemical transformation - often a hydrolysis reaction - in the polymer side chain or backbone. An overview of the different approaches used for the design of these polymers along with their physicochemical properties is given. Their amphiphilic properties and degradability into fully soluble compounds make this class of responsive polymers attractive for drug delivery and tissue engineering applications. Examples of these are also provided in this review.
本次综述的重点是瞬态温敏聚合物这一类。这类聚合物具有温敏性，但在聚合物侧链或主链发生化学转化（通常是水解反应）后，这种特性会逐渐丧失。本文概述了设计这类聚合物的不同方法及其理化性质。其两亲性和完全可溶化合物的降解能力使这类响应性聚合物成为药物输送和组织工程应用的理想选择。本文也提供了这方面的一些实例。
