Guo Yingshu, Sun Li, Wang Yajing, Wang Qianqian, Jing Dan, Liu Shiwei
Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
School of Chemistry and Chemical Engineering, Linyi University, Linyi, China.
Front Chem. 2022 Sep 21;10:946183. doi: 10.3389/fchem.2022.946183. eCollection 2022.
The progress of nanotechnology enables us to make use of the special properties of materials on the nanoscale and open up many new fields of biomedical research. Among them, thermosensitive nanomaterials stand out in many biomedical fields because of their "intelligent" behavior in response to temperature changes. However, this article mainly reviews the research progress of thermosensitive nanomaterials, which are popular in biomedical applications in recent years. Here, we simply classify the thermally responsive nanomaterials according to the types of polymers, focusing on the mechanisms of action and their advantages and potential. Finally, we deeply investigate the applications of thermosensitive nanomaterials in drug delivery, tissue engineering, sensing analysis, cell culture, 3D printing, and other fields and probe the current challenges and future development prospects of thermosensitive nanomaterials.
纳米技术的进步使我们能够利用纳米级材料的特殊性质,并开辟了许多生物医学研究的新领域。其中,热敏纳米材料因其对温度变化的“智能”响应行为,在许多生物医学领域脱颖而出。然而,本文主要综述了近年来在生物医学应用中备受关注的热敏纳米材料的研究进展。在此,我们根据聚合物类型对热敏纳米材料进行了简单分类,重点介绍了其作用机制、优点及潜力。最后,我们深入探讨了热敏纳米材料在药物递送、组织工程、传感分析、细胞培养、3D打印等领域的应用,并探究了热敏纳米材料当前面临的挑战和未来的发展前景。