Foldes J, Naparstek E, Statter M, Menczel J, Bab I
Department of Medicine, Hadassah Mount Scopus University Hospital, Jerusalem, Israel.
J Bone Miner Res. 1989 Aug;4(4):643-6. doi: 10.1002/jbmr.5650040424.
It has been shown recently in experimental animals that regeneration of bone marrow after ablation is associated with enhanced osteogenic growth factor activity and a systemic increase in bone formation. To assess the possible occurrence of a similar phenomenon in humans, serum markers of bone formation, osteocalcin and alkaline phosphatase, were measured in marrow donors before the aspiration of large amounts of iliac marrow and 1 day to 5 weeks thereafter. Both osteocalcin and alkaline phosphatase showed significant increases, with peak values 1-3 and 2-4 weeks postaspiration, respectively. The absolute maximal increase in osteocalcin was significantly higher in adolescent and child donors than in adults. When evaluated together with studies on systemic changes during fracture healing and marrow regeneration, these findings suggest that marrow aspiration in humans evokes a systemic osteogenic response.
最近在实验动物中发现，骨髓消融后的再生与成骨生长因子活性增强以及骨形成的全身性增加有关。为了评估人类中是否可能发生类似现象，在大量抽取髂骨骨髓之前以及之后1天至5周，对骨髓捐献者的骨形成血清标志物骨钙素和碱性磷酸酶进行了测量。骨钙素和碱性磷酸酶均显著增加，峰值分别出现在抽吸后1 - 3周和2 - 4周。青少年和儿童捐献者骨钙素的绝对最大增加量显著高于成年人。结合骨折愈合和骨髓再生过程中全身变化的研究进行评估时，这些发现表明，人类骨髓抽吸会引发全身性成骨反应。
