假设：甲状腺功能减退病史或恶性贫血家族史有助于识别老年小细胞低色素性贫血患者中的隐匿性恶性贫血。

Hypothesis: a history of hypothyroidism or a family history of pernicious anaemia are useful in identifying masked pernicious anaemia in elderly patients with microcytic hypochromic anaemia.

作者信息

Catania J, Chaudhuri M D, Sitlani P K, Mannakkara J V

机构信息

Department of Geriatric Medicine, Withington Hospital, Manchester.

出版信息

Age Ageing. 1989 Jul;18(4):279-81. doi: 10.1093/ageing/18.4.279.

DOI:10.1093/ageing/18.4.279

PMID:2816563

Abstract

Of 2200 consecutive patients admitted to an acute geriatric unit, 58 had microcytic hypochromic anaemia. Twenty of these (34%) had serum vitamin B12 below the normal range. Eleven (19%) had malabsorption of vitamin B12 in eight of whom (14%) this was due to pernicious anaemia (PA). This study re-emphasizes the need for screening for PA in patients with microcytic hypochromic anaemia, particularly those with a family history or who have recognized associated diseases.

摘要

在连续入住一家急性老年病科的2200名患者中，58人患有小细胞低色素性贫血。其中20人（34%）血清维生素B12低于正常范围。11人（19%）存在维生素B12吸收不良，其中8人（14%）是由于恶性贫血（PA）。本研究再次强调，对于小细胞低色素性贫血患者，尤其是有家族史或已确诊相关疾病的患者，有必要进行PA筛查。