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原发性自身免疫性甲状腺功能减退症与艾迪生病贫血的关联

[Association of primary autoimmune hypothyroidism with Addison's anemia].

作者信息

Gasińska T, Izbicka M, Kierat A

机构信息

I Klinika Chorób Wewnetrznych Slaskiej AM w Katowicach.

出版信息

Endokrynol Pol. 1991;42(3):407-13.

PMID:1364489
Abstract

Intestinal absorption of vitamin B12 as measured by the Schillin test was studied in 50 patients with primary hypothyroidism of autoimmune origin. The impaired absorption of vitamin B12 was found in 24% of the patients studied, and in 6% a clinically evident form of pernicious anemia was diagnosed. The patients with hypothyroidism and simultaneous defect in absorption of vitamin B12 were characterized by more frequent occurrence of the high titer of antithyroid microsomal antibodies, higher blood serum concentration of TSH and lower blood content of hemoglobin as compared with hypothyroid patients having normal intestinal absorption of vitamin B12.

摘要

通过希林试验测定了50例自身免疫性原发性甲状腺功能减退患者维生素B12的肠道吸收情况。在所研究的患者中,发现24%存在维生素B12吸收受损,6%被诊断为临床明显的恶性贫血。与维生素B12肠道吸收正常的甲状腺功能减退患者相比,甲状腺功能减退且同时存在维生素B12吸收缺陷的患者具有抗甲状腺微粒体抗体高滴度更频繁出现、血清促甲状腺激素浓度更高以及血红蛋白血含量更低的特点。

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