Tozuka K, Hara Y, Moriguchi H, Kikuchi T, Tokue A
Department of Urology, Jichi Medical School.
Hinyokika Kiyo. 1989 Sep;35(9):1475-8.
The density of calcium phosphate and the pH were determined in 15 postprandial urine specimens with heavy precipitation of amorphous calcium phosphate, that is phosphaturia, collected from 5 patients with calcium urolithiasis (stone-formers) and 3 patients with no known urological disease (controls). Phosphaturia, not related to urinary tract infection or administration of alkalinizing agents, was found repeatedly at our outpatient clinic in these patients. The correlative relationship was not confirmed between the density of calcium phosphate and the pH. The concentration of calcium and phosphorus was also determined in 10 urine specimens with phosphaturia. The concentration of phosphorus was correlated significantly with the pH (r = -0.775, p less than 0.01), although the concentration of calcium was not correlated with the pH. The pH of 11 urine specimens with phosphaturia from the controls was 7.51 +/- 0.31 (mean +/- S.D.) and the pH of 18 urine specimens with phosphaturia from the stone-formers was 6.81 +/- 0.34. The pH was significantly lower in the urine specimens from the stone-formers than in those from the controls (p less than 0.01). We have noted that the occurrence of phosphaturia depends not only on the urinary pH but on the concentration of phosphorus. It is interesting that phosphaturia often occurs in urine specimens with a pH below 7 in stone-formers.
对5例钙尿路结石患者（结石形成者）和3例无已知泌尿系统疾病的患者（对照组）的15份餐后尿液标本进行了磷酸钙密度和pH值测定，这些标本中有大量无定形磷酸钙沉淀，即磷尿症。在我们的门诊中，这些患者反复出现与尿路感染或服用碱化剂无关的磷尿症。未证实磷酸钙密度与pH值之间存在相关性。还对10份有磷尿症的尿液标本进行了钙和磷浓度测定。磷浓度与pH值显著相关（r = -0.775，p < 0.01），而钙浓度与pH值无相关性。对照组11份有磷尿症的尿液标本pH值为7.51±0.31（平均值±标准差），结石形成者18份有磷尿症的尿液标本pH值为6.81±0.34。结石形成者的尿液标本pH值显著低于对照组（p < 0.01）。我们注意到，磷尿症的发生不仅取决于尿液pH值，还取决于磷的浓度。有趣的是，结石形成者中，磷尿症常发生在pH值低于7的尿液标本中。
