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移植受者中的耐多药结核病:病例报告及文献综述

Multidrug-resistant tuberculosis in transplant recipients: Case report and review of the literature.

作者信息

Huaman Moises A, Brawley Robert, Ashkin David

机构信息

Division of Infectious Diseases, University of Kentucky College of Medicine, Lexington, KY, USA.

Kentucky Department for Public Health, Frankfort, KY, USA.

出版信息

Transpl Infect Dis. 2017 Apr;19(2). doi: 10.1111/tid.12672. Epub 2017 Mar 16.

Abstract

Transplant recipients are at increased risk of tuberculosis (TB). We describe a case of pulmonary and vertebral multidrug-resistant TB (MDR-TB) in a kidney transplant patient who required neurosurgical intervention and unfortunately developed fatal nosocomial complications. Thirteen transplant recipients with MDR-TB were previously reported in the literature (one hematopoietic cell transplant, one heart transplant, one lung transplant, one heart-lung transplant, and nine kidney transplant recipients). Extrapulmonary disease, severe treatment complications, and deaths were observed in patients who developed MDR-TB after transplantation.

摘要

移植受者患结核病(TB)的风险增加。我们描述了一例肾移植患者发生肺和脊柱耐多药结核病(MDR-TB)的病例,该患者需要神经外科干预,不幸的是出现了致命的医院感染并发症。文献中此前报道了13例移植受者发生MDR-TB(1例造血细胞移植、1例心脏移植、1例肺移植、1例心肺移植和9例肾移植受者)。移植后发生MDR-TB的患者出现了肺外疾病、严重的治疗并发症和死亡情况。

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