Rashid Harun Ur, Begum Nura Afza Salma, Kashem Tasnuva Sarah
Department of Nephrology, Kidney Foundation Hospital and Research Institute, Dhaka, Bangladesh.
Korean J Transplant. 2021 Dec 31;35(4):208-217. doi: 10.4285/kjt.21.0033.
(MTB) infection in solid organ transplant (SOT) recipients remains a major challenge for physicians and surgeons. Active tuberculosis (TB) is associated with increased morbidity and mortality in SOT recipients. MTB usually develops after transplantation in a recipient with latent TB infection (LTBI) before transplantation and may also be transmitted from the donor or acquired from the community. Therefore, screening for LTBI in donors and recipients before transplantation is very important in preventing active disease after transplantation. This review article is based on recently published data, case series, and expert recommendations. We reviewed updated information about the epidemiology, diagnosis, and treatment of latent and active TB before and after transplantation. We also reviewed recent treatments for multidrug-resistant TB.
实体器官移植（SOT）受者中的结核分枝杆菌（MTB）感染仍然是内科医生和外科医生面临的一项重大挑战。活动性结核病（TB）与SOT受者发病率和死亡率的增加相关。MTB通常在移植后发生于移植前有潜伏性结核感染（LTBI）的受者，也可能从供体传播或从社区获得。因此，移植前对供体和受者进行LTBI筛查对于预防移植后活动性疾病非常重要。这篇综述文章基于最近发表的数据、病例系列和专家建议。我们回顾了关于移植前后潜伏性和活动性结核病的流行病学、诊断和治疗的最新信息。我们还回顾了耐多药结核病的最新治疗方法。
