Radahmadi Maryam, Alaei Hojjatallah, Sharifi Mohammad Reza, Hosseini Nasrin
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Bodyw Mov Ther. 2017 Jan;21(1):63-68. doi: 10.1016/j.jbmt.2016.05.002. Epub 2016 Jun 1.
Stress is one of the most significant causes of major health problems on a global scale. The beneficial effects of exercise on combating stress, however, are well-established. The present study investigated the stress biomarker responses, such as serum corticosterone, interlukin-1β, and glucose levels, to different (preventive, therapeutic, protective, and continuous) protocols of forced exercise under stress. Male rats were randomly allocated to the following five groups: stressed, preventive, therapeutic, protective, and continuous (and/or pre-stress, post-stress, stress-accompanied, and both pre-stress and stress-accompanied exercise respectively) exercise groups. Stress was applied 6 h/day for 21 days and the treadmill running was employed at a speed of 20-21 m/min for 21 and 42 days. The findings showed that the therapeutic, protective, and continuous exercises led to reduced corticosterone and glucose levels. Whereas, the preventive exercise did not reverse the stress responses, and that the therapeutic exercise led to a significant decline in serum interlukin-1β. It is concluded that protective, therapeutic, and, particularly, continuous exercises lead to significant reductions in serum corticosterone and the associated stress-induced hyperglycemia. Moreover, it appears that the timing and duration of exercise are the two factors contributing to changes in stress biomarker responses.
压力是全球范围内导致重大健康问题的最重要原因之一。然而，运动对对抗压力的有益作用已得到充分证实。本研究调查了在压力下不同（预防、治疗、保护和持续）强制运动方案对压力生物标志物反应的影响，如血清皮质酮、白细胞介素-1β和葡萄糖水平。雄性大鼠被随机分为以下五组：应激组、预防运动组、治疗运动组、保护运动组和持续运动组（以及分别进行应激前、应激后、应激伴随和应激前及应激伴随运动）。每天施加6小时压力，持续21天，并在21天和42天内以20-21米/分钟的速度进行跑步机跑步。研究结果表明，治疗性运动、保护性运动和持续运动导致皮质酮和葡萄糖水平降低。而预防性运动并未逆转应激反应，且治疗性运动导致血清白细胞介素-1β显著下降。结论是，保护性运动、治疗性运动，特别是持续运动可导致血清皮质酮和相关应激诱导的高血糖症显著降低。此外，运动的时间和持续时间似乎是导致压力生物标志物反应变化的两个因素。
