Lucas Geoff, Culliford Steven, Bendukidze Nina, Dahlstrom Julia, Grandage Victoria, Carpenter Ben, Hough Rachael
Histocompatibility & Immunogenetics, National Blood and Transplant, Filton, UK.
Histocompatibility & Immunogenetics, National Blood and Transplant, Filton, UK.
Transpl Immunol. 2017 Mar;41:32-36. doi: 10.1016/j.trim.2017.02.002. Epub 2017 Feb 4.
This report describes a patient who received an allogeneic haematopoietic stem cell transplant and who, following a viral infection, developed late onset cytopenias associated with antibodies against red cells, platelets and granulocytes. Investigation of these cytopenias revealed the presence of lineage specific auto- and allo-antibodies, which were not present in either the donor or in the recipient prior to the viral infection. This case provides further evidence for the concept that viral challenges following HSCT can result in the production of cell specific antibodies that can have significant implications for patient management.
本报告描述了一名接受异基因造血干细胞移植的患者，该患者在病毒感染后出现了与抗红细胞、血小板和粒细胞抗体相关的迟发性血细胞减少。对这些血细胞减少的调查显示存在谱系特异性自身抗体和同种抗体，这些抗体在病毒感染前供体和受体中均不存在。该病例为以下概念提供了进一步证据：造血干细胞移植后的病毒挑战可导致产生细胞特异性抗体，这可能对患者管理产生重大影响。
