Wang Hua, Liu Mengmeng, Yang Jianqiu, Song Yimin
Ultrasound Department of the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Pathology Department of the Third People's Hospital of Zhengzhou, Zhengzhou, China.
Pak J Pharm Sci. 2016 Nov;29(6 Suppl):2269-2271.
To study high-frequency ultrasound features and pathological characteristics of medullary thyroid carcinoma (medullary thyroid carcinoma, MTC) with the purpose to improve the diagnostic accuracy of this disease. The clinical data of 20 cases of patients with MTC confirmed by the clinical surgery were retrospectively analyzed. And the high-frequency ultrasound features were analyzed and compared with the pathological characteristics. There were 16 cases with tumor invasion into one side of the thyroid gland; 17 cases with tumor in the middle-upper pole of the thyroid gland. And 8 cases were detected with uneven echo of high frequency ultrasound appearance and pathological manifestations of cystic degeneration to necrosis seen under the light microscope or normal thyroid tissue within part of the lump. 16 cases were tested with even echo of high frequency ultrasound appearance, and tumor cells were formed in the solid and block-like shape under the light microscope. And 18 cases were manifested with low echo, with proliferation of fibrous tissue within the intercellular substance under the light microscope. 18 cases could be seen the calcification points and often amyloid-like content deposited in the intercellular substance seen under the light microscope. In addition, the pathological manifestations of the 8 cases combined with lymph node metastasis were the "lash tumor" of the metastatic lymph nodes and primary tumor. MTC was commonly located in the middle-upper region of the thyroid gland and in one leaf of the thyroid gland, combined with lymph node metastasis. The high frequency ultrasound appearance was the even low-echo tumor in round or quasi-circular shape, with obscure boundary and often combined with rough calcification. High frequency ultrasound could be used as the prior physical diagnostic method for medullary thyroid carcinoma.
研究甲状腺髓样癌（MTC）的高频超声特征及病理特点，以提高该病的诊断准确性。回顾性分析20例经临床手术确诊的MTC患者的临床资料，并对高频超声特征进行分析，与病理特点进行对比。16例肿瘤侵犯甲状腺一侧叶；17例肿瘤位于甲状腺中上极。8例高频超声表现为回声不均匀，病理表现为光镜下可见部分肿块内有囊性变至坏死，或有正常甲状腺组织。16例高频超声表现为回声均匀，光镜下肿瘤细胞呈实性块状排列。18例表现为低回声，光镜下细胞间可见纤维组织增生。18例光镜下可见钙化点，细胞间常可见淀粉样物质沉积。此外，8例合并淋巴结转移者的病理表现为转移淋巴结及原发肿瘤呈“鞭梢样肿瘤”。MTC多位于甲状腺中上区及一侧叶，合并淋巴结转移。高频超声表现为圆形或类圆形均匀低回声肿瘤，边界不清，常合并粗糙钙化。高频超声可作为甲状腺髓样癌的首选物理诊断方法。
