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儿科暴露于兽用医药产品。

Pediatric Exposures to Veterinary Pharmaceuticals.

机构信息

Center for Injury Research and Policy, The Research Institute, and.

Department of Veterinary Preventive Medicine, College of Veterinary Medicine.

出版信息

Pediatrics. 2017 Mar;139(3). doi: 10.1542/peds.2016-1496. Epub 2017 Feb 6.

Abstract

OBJECTIVE

To describe the epidemiology of veterinary pharmaceutical-related exposures to children based on calls to a regional poison control center.

METHODS

A retrospective analysis of pediatric (≤19 years of age) exposures to pharmaceutical products intended for animal use, managed by a regional poison control center from 1999 through 2013, was conducted. Case narratives were reviewed and coded for exposure-related circumstances and intended species. Descriptive statistics were generated.

RESULTS

From 1999 through 2013, the Central Ohio Poison Center received 1431 calls that related to a veterinary pharmaceutical exposure for children ≤19 years of age. Most of the pediatric calls (87.6%) involved children ≤5 years of age. Exploratory behavior was the most common exposure-related circumstance (61.4%) and ingestion accounted for the exposure route in 93% of cases. Substances commonly associated with exposures included: veterinary drugs without human equivalent (17.3%), antimicrobial agents (14.8%), and antiparasitics (14.6%). Based on substance and quantity, the majority of exposures (96.9%) were not expected to result in long-term or lasting health effects and were managed at home (94.1%). A total of 80 cases (5.6%) were referred to a health care facility, and 2 cases resulted in a moderate health effect.

CONCLUSIONS

Children ≤5 years of age are most at risk for veterinary pharmaceutical-related exposures. Although most exposures do not result in a serious medical outcome, efforts to increase public awareness, appropriate product dispensing procedures, and attention to home storage practices may reduce the risk of veterinary pharmaceutical exposures to young children.

摘要

目的

根据区域中毒控制中心的报告,描述兽医制药相关暴露对儿童的流行病学情况。

方法

对 1999 年至 2013 年期间由区域中毒控制中心管理的儿童(≤19 岁)因使用兽用药品导致的暴露进行回顾性分析。对案例叙述进行了审查和编码,以确定与暴露相关的情况和预期的物种。生成了描述性统计数据。

结果

1999 年至 2013 年期间,俄亥俄州中部中毒中心共接到 1431 个儿童(≤19 岁)因兽医制药暴露而致电的电话。大多数儿科电话(87.6%)涉及≤5 岁的儿童。探索性行为是最常见的暴露相关情况(61.4%),93%的病例中暴露途径是摄入。与暴露相关的常见物质包括:无人类等效物的兽医药物(17.3%)、抗菌药物(14.8%)和抗寄生虫药(14.6%)。根据物质和数量,大多数暴露(96.9%)预计不会导致长期或持久的健康影响,并且在家中得到管理(94.1%)。共有 80 例(5.6%)被转至医疗机构,其中 2 例导致中度健康影响。

结论

≤5 岁的儿童最容易受到兽医制药相关暴露的影响。尽管大多数暴露不会导致严重的医疗后果,但增加公众意识、适当的产品配药程序和注意家庭储存实践的努力可能会降低幼儿接触兽医制药的风险。

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