Lešták Jan, Tintěra Jaroslav, Karel Ivan, Svatá Zuzana, Rozsíval Pavel
JL ClinicV Hůrkách 1296/10, PragueCzech Republic; Faculty of Biomedical Engineering, Czech Technical University in PraguePragueCzech Republic; Faculty of Medicine in Hradec Králové, Charles University, Hradec KrálovéCzech Republic.
JL Clinic V Hůrkách 1296/10, Prague Czech Republic.
Neuroophthalmology. 2013 Sep 24;37(5):192-197. doi: 10.3109/01658107.2013.819581. eCollection 2013.
The study is designed to determine the relationship between the progress of the wet form of age-related macular degeneration and the activity of the visual cortex examined using functional magnetic resonance imaging. Ten patients with the wet form of age-related macular degeneration (9 female and 1 male) with a mean age of 74.7 years (58-85 years) at various stages of bilateral involvement of the disease were included. Patients did not suffer from any other ocular nor neurological disease. All the patients underwent functional magnetic resonance imaging examinations with stimulation of both eyes using a black-and-white checkerboard of size 25.8 × 16.2 degrees. The group was compared with a group of healthy subjects with an average age of 54.1 years (45-65 years). For statistical evaluation, the Mann-Whitney test was used. Comparing the extent of visual cortex activations we found a statistically significant difference between both the groups ( = 0.0247). However, the dependence of functional magnetic resonance imaging activity on visual acuity was not statistically significant ( = 0.223). We conclude that in patients with the wet form of age-related macular degeneration, lower functional magnetic resonance imaging activity of the visual cortex was found compared with the control group of healthy subjects. Dependence of functional magnetic resonance imaging activity on visual acuity was not statistically significant.
该研究旨在确定湿性年龄相关性黄斑变性的进展与使用功能磁共振成像检查的视觉皮层活动之间的关系。纳入了10例湿性年龄相关性黄斑变性患者（9例女性，1例男性），平均年龄74.7岁（58 - 85岁），处于疾病双侧受累的不同阶段。患者未患有任何其他眼部或神经系统疾病。所有患者均接受了功能磁共振成像检查，使用大小为25.8×16.2度的黑白棋盘格刺激双眼。将该组患者与平均年龄为54.1岁（45 - 65岁）的健康受试者组进行比较。进行统计评估时，使用了曼 - 惠特尼检验。比较视觉皮层激活程度时，我们发现两组之间存在统计学显著差异（= 0.0247）。然而，功能磁共振成像活动与视力之间的相关性无统计学意义（= 0.223）。我们得出结论，与健康受试者对照组相比，湿性年龄相关性黄斑变性患者的视觉皮层功能磁共振成像活动较低。功能磁共振成像活动与视力之间的相关性无统计学意义。
