早期年龄相关性黄斑变性与脑部磁共振成像变化有关吗？社区动脉粥样硬化风险研究。
Is early age-related macular degeneration associated with cerebral MRI changes? The Atherosclerosis Risk in Communities study.
作者信息
Grosso Andrea, Mosley Thomas H, Klein Ronald, Couper David J, Tikellis Gabriella, Wong Tien Y
机构信息
Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia.
出版信息
Am J Ophthalmol. 2007 Jan;143(1):157-9. doi: 10.1016/j.ajo.2006.07.040. Epub 2006 Aug 31.
PURPOSE
To examine the relation of early age-related macular degeneration (AMD) with cerebral magnetic resonance imaging (MRI) changes.
DESIGN
Population-based, cross-sectional study.
METHODS
A sample of 1,684 persons ages 51 to 72 years with no history of stroke had cerebral MRI and retinal photography. MRI scans were graded for severity of white matter lesions (WML), sulcal widening (SW), and ventricular enlargement (VE). AMD was graded from retinal photographs.
RESULTS
After adjustment for age, gender, race, or center, early AMD (5.0% of participants) was not significantly associated with WML (odds ratio [OR] 1.0, 95% confidence intervals [CI], 0.6 to 1.6), SW (OR 0.6, 95% CI, 0.4 to 1.2), or VE (OR 1.0, 95% CI, 0.6 to 1.8).
CONCLUSIONS
These data showed no statistically significant association of early AMD with cerebral MRI changes, but the study was limited by a small number of cases with wide CIs. Further studies may clarify these associations.
目的
研究早期年龄相关性黄斑变性（AMD）与脑磁共振成像（MRI）变化之间的关系。
设计
基于人群的横断面研究。
方法
对1684名年龄在51至72岁且无中风病史的人进行脑MRI和视网膜摄影。对MRI扫描的白质病变（WML）、脑沟增宽（SW）和脑室扩大（VE）的严重程度进行分级。从视网膜照片中对AMD进行分级。
结果
在对年龄、性别、种族或中心进行调整后，早期AMD（占参与者的5.0%）与WML（优势比[OR]1.0，95%置信区间[CI]，0.6至1.6）、SW（OR 0.6，95%CI，0.4至1.2）或VE（OR 1.0，95%CI，0.6至1.8）均无显著相关性。
结论
这些数据显示早期AMD与脑MRI变化之间无统计学上的显著关联，但该研究受限于病例数量少且置信区间宽。进一步的研究可能会阐明这些关联。
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