Bingol Kiziltunc Pinar, Atilla Huban, Yalcindag F Nilufer
Department of Ophthalmology, Faculty of Medicine, Ankara University Dikimevi, Ankara Turkey.
Neuroophthalmology. 2013 Nov 19;37(6):257-259. doi: 10.3109/01658107.2013.830227. eCollection 2013.
We present a case in which Gilbert syndrome was diagnosed following a neuro-ophthalmic complaint. Adverse effects of drugs as well as various systemic, neurological, and local ocular pathologies can cause accommodative insufficiency and loss of accommodation. A 29-year-old man was admitted to an ophthalmology department with blurred vision and diagnosed as suffering from acute accommodation paralysis. He had a history of being given a pheniramine maleate injection for pruritus 20 days previously. Symptoms began immediately following the injection. After systemic evaluation and laboratory tests, he was diagnosed as having Gilbert syndrome. His complaints and symptoms recovered in approximately a further 10 days. Metabolism of pheniramine maleate can be impaired in Gilbert syndrome and anticholinergic effects can cause accommodation paralysis.
我们报告一例因神经眼科主诉而诊断为吉尔伯特综合征的病例。药物的不良反应以及各种全身性、神经性和局部眼部疾病均可导致调节功能不全和调节丧失。一名29岁男性因视力模糊入住眼科，被诊断为急性调节麻痹。他有20天前因瘙痒接受马来酸氯苯那敏注射的病史。注射后症状立即出现。经过全身评估和实验室检查，他被诊断为吉尔伯特综合征。大约再过10天，他的主诉和症状就恢复了。在吉尔伯特综合征中，马来酸氯苯那敏的代谢可能受损，其抗胆碱能作用可导致调节麻痹。
