马来酸氯苯那敏诱发横纹肌溶解导致的急性肾衰竭：一例罕见病例。
Acute renal failure caused by pheniramine maleate induced rhabdomyolysis: an unusual case.
作者信息
Paul G, Sood P, Paul B S, Puri S
机构信息
Critical Care Team, Dyanand Medical College and Hospital, Ludhiana, India.
出版信息
Indian J Crit Care Med. 2009 Oct;13(4):221-3. doi: 10.4103/0972-5229.60176.
Abstract
Antihistamines are easily available over-the-counter medications, which are frequently involved in overdoses. The usual course is accompanied by the anticholinergic effects of these agents. We report a case of a suicide attempt in a young male, where ingestion of antihistamine pheniramine maleate was complicated by nontraumatic rhabdomyolysis and oliguric acute renal failure. Rhabdomyolysis and acute renal failure is a rarely reported but potentially serious complication among patients who present to the emergency after intentional overdoses making recognition and prompt intervention essential. We also describe the potential mechanism of muscle injury in antihistamine overdose.
摘要
抗组胺药是很容易买到的非处方药，经常会发生过量服用的情况。这些药物的常规疗程会伴有抗胆碱能效应。我们报告一例年轻男性自杀未遂病例，该患者因过量服用马来酸氯苯那敏而并发非创伤性横纹肌溶解和少尿性急性肾衰竭。横纹肌溶解和急性肾衰竭是故意过量服药后到急诊科就诊的患者中很少报道但可能很严重的并发症，因此识别和及时干预至关重要。我们还描述了抗组胺药过量导致肌肉损伤的潜在机制。
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本文引用的文献
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