Garry P J, Hunt W C, VanderJagt D J, Rhyne R L
University of New Mexico, School of Medicine, Department of Pathology and Family, Albuquerque 87131.
Am J Clin Nutr. 1989 Nov;50(5 Suppl):1219-30; discussion 1231-5. doi: 10.1093/ajcn/50.5.1219.
In 1979, 304 healthy elderly individuals in New Mexico were recruited for a longitudinal study of nutrition and aging. Repeat measurements on a yearly basis of commonly requested clinical chemistry analytes allowed the calculation of reference intervals, between and within-subject variance components, and percentiles for change in concentration between two yearly measurements. The latter was further divided into analytical and biological variance components. The upper 95th percentile for the difference between two yearly measurements, expressed as a percent of the population mean, ranged from 4% for Na+ to approximately 20% for total cholesterol and to greater than 90% for ferritin. Year-to-year differences attributable to the biological component ranged from a low of 2% of the population mean for Na+ to 70% for gamma-glutamyltransferase.
1979年，新墨西哥州的304名健康老年人被招募参加一项关于营养与衰老的纵向研究。每年对常见的临床化学分析物进行重复测量，从而能够计算参考区间、受试者间和受试者内的方差成分，以及两次年度测量之间浓度变化的百分位数。后者进一步细分为分析方差成分和生物学方差成分。两次年度测量之间差异的第95百分位数上限，以占总体均值的百分比表示，从钠离子的4%到总胆固醇的约20%，再到铁蛋白的超过90%不等。归因于生物学成分的年度差异范围从钠离子占总体均值的低至2%到γ-谷氨酰转移酶的70%。
