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[巴黎地区一组健康老年人群的参考区间和生物学特征]

[Reference intervals and biological profile in a group of healthy elderly population in the Paris region].

作者信息

Cals M J, Bories P N, Blondé-Cynober F, Coudray-Lucas C, Desveaux N, Devanlay M, Duché J C, Luciani L, Meneguzzer E, Pontézière C, Succari M, Tortrat D

机构信息

Laboratoire de biologie hôpital Corentin-Celton, Issy-Les Moulineaux. France.

出版信息

Ann Biol Clin (Paris). 1996;54(7):307-15.

PMID:8952729
Abstract

The superimposition of pathological processes on ageing-related metabolic changes makes the interpretation of laboratory data difficult in the elderly. Therefore, in order to establish reference values of anthropometric, hematological and biochemical variables, we have carefully selected fit, health-conscious elderly subjects on the basis of clinical and biological criteria. We observed a trend for a wider range of values than in young adults. For some variables, the values were shifted down (eg: albumin, vitamin D) or up (eg: glucose, urea, cholesterol, ferritin), as a result of slow metabolic changes or progressive functional decline of different organs. The high prevalence of hypovitaminosis D was worthy of note, particularly in women, suggesting a high risk of deficiency.

摘要

病理过程叠加在与衰老相关的代谢变化上,使得老年人实验室数据的解读变得困难。因此,为了建立人体测量学、血液学和生化变量的参考值,我们根据临床和生物学标准精心挑选了健康、注重健康的老年受试者。我们观察到,与年轻人相比,这些变量的值范围有更宽的趋势。由于代谢变化缓慢或不同器官的功能逐渐衰退,某些变量的值向下偏移(如白蛋白、维生素D)或向上偏移(如葡萄糖、尿素、胆固醇、铁蛋白)。维生素D缺乏症的高患病率值得注意,尤其是在女性中,这表明存在较高的缺乏风险。

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