Department of Radiation Oncology, Faculty of Medicine, Karadeniz Technical University, 61100, Trabzon, Turkey.
Department of Radiation Oncology, Avrasya Hospital, Beştelsiz Mah., 101., Sok., No:107, Akşemsettin Tramvay Durağı, Zeytinburnu, 34020, Istanbul, Turkey.
Biol Trace Elem Res. 2017 Sep;179(1):110-116. doi: 10.1007/s12011-017-0952-z. Epub 2017 Feb 6.
Growth hormone (GH) and zinc (Zn) were evaluated for their potential to prevent radiation injury using a rat model of radiation-induced skin injury. Sprague-Dawley rats were divided into five groups: a control group not receiving Zn, GH, or irradiation: a radiation (RT) group receiving a single 30 Gy dose of gamma irradiation to the right hind legs; a radiation + GH group (RT + GH) receiving a single 30 Gy dose of gamma irradiation plus the subcutaneous administration of 0.01 IU kg d GH; a radiation + Zn group (RT + Zn) receiving a single 30 Gy dose plus 5 mg kg d Zn po; and a radiation + GH + Zn group (RT + GH + Zn) group receiving a single 30 Gy dose plus subcutaneous 0.01 IU kg d GH and 5 mg kg d Zn po. Acute skin reactions were assessed every 3 days by two radiation oncologists grouping. Light microscopic findings were assessed blindly by two pathologists. Groups receiving irradiation were associated with dermatitis as compared to the control group (P < 0.05). The severity of radiodermatitis in the RT + GH, RT + Zn, and RT + GH + Zn groups was significantly lower than that in the RT group (P < 0.05). Furthermore, radiodermatitis was observed earlier in the RT group than in the other treatment groups (P < 0.05). GH and Zn effectively prevented epidermal atrophy, dermal degeneration, and hair follicle atrophy. The highest level of protection against radiation dermatitis was observed in the combination group.
生长激素（GH）和锌（Zn）被评估用于预防辐射损伤的潜力，使用了一种辐射诱导皮肤损伤的大鼠模型。Sprague-Dawley 大鼠被分为五组：一组未接受 Zn、GH 或照射的对照组；一组接受单次 30Gy 剂量 γ 射线照射右侧后腿的辐射（RT）组；一组接受单次 30Gy 剂量 γ 射线照射加皮下注射 0.01IUkgd GH 的辐射+GH 组（RT+GH）；一组接受单次 30Gy 剂量加 5mgkgd po Zn 的辐射+Zn 组（RT+Zn）；一组接受单次 30Gy 剂量加皮下注射 0.01IUkgd GH 和 5mgkgd Zn po 的辐射+GH+Zn 组（RT+GH+Zn）。由两名放射肿瘤学家分组，每 3 天评估一次急性皮肤反应。两名病理学家盲法评估光镜检查结果。与对照组相比，接受照射的组与皮炎相关（P<0.05）。与 RT 组相比，RT+GH、RT+Zn 和 RT+GH+Zn 组的放射性皮炎严重程度明显降低（P<0.05）。此外，RT 组的放射性皮炎比其他治疗组更早出现（P<0.05）。GH 和 Zn 可有效预防表皮萎缩、真皮变性和毛囊萎缩。联合组对辐射性皮炎的保护作用最强。
