Zhang Ying, Wei Xuebo, Xu Yun, Xia Weidong, Zheng ChaoYu, Zhang Hongyu, Chen Weiting, Xu Ke, Huang Qun
The Third People's Hospital Health Care Group of Cixi, Ningbo, China.
College of Life and Environmental Sciences, Wenzhou University, Wenzhou, China.
Regen Ther. 2025 Feb 14;28:582-590. doi: 10.1016/j.reth.2025.01.022. eCollection 2025 Mar.
Delayed healing of skin wounds significantly impacts human life, Zinc plays a pivotal role in human growth, the immune system, and various cellular processes. Previous studies have demonstrated that zinc supplementation or topical zinc ion therapy can accelerate wound healing in cases of skin injury. Zinc deficiency has been linked to delayed wound healing, but the role it plays remains to be elucidated. In this study, we report the preparation of zinc sulfate gel to promote wound healing by treating inflammation, antioxidant effects, and angiogenesis. We demonstrated the efficacy of zinc sulfate gel in wound healing in a mouse model of full-thickness skin excision, spared the anti-inflammatory and antioxidant capabilities of zinc ions. Furthermore, Zinc sulfate gel can stimulate tissue to enter the proliferative phase by regulating macrophage polarization, thereby accelerating collagen deposition, granulation tissue formation, and extracellular matrix production and remodeling. In conclusion, zinc ion gel provides a promising strategy for skin wounds regeneration.
皮肤伤口愈合延迟对人类生活有重大影响，锌在人类生长、免疫系统及各种细胞过程中起着关键作用。先前的研究表明，补充锌或局部锌离子疗法可加速皮肤损伤情况下的伤口愈合。锌缺乏与伤口愈合延迟有关，但其所起的作用仍有待阐明。在本研究中，我们报告了硫酸锌凝胶的制备，其通过治疗炎症、抗氧化作用和血管生成来促进伤口愈合。我们在全层皮肤切除小鼠模型中证明了硫酸锌凝胶在伤口愈合中的功效，证实了锌离子的抗炎和抗氧化能力。此外，硫酸锌凝胶可通过调节巨噬细胞极化刺激组织进入增殖期，从而加速胶原蛋白沉积、肉芽组织形成以及细胞外基质的产生和重塑。总之，锌离子凝胶为皮肤伤口再生提供了一种有前景的策略。
