Yuk Seong-Su, Erdene-Ochir T O, Kwon Jung-Hoon, Noh Jin-Yong, Hong Woo-Tack, Jeong Jei-Hyun, Jeong Sol, Gwon Gyeong-Bin, Shin Jong-Il, Sur Jung-Hyang, Song Chang-Seon
Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.
Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.
Vaccine. 2017 Mar 1;35(9):1316-1322. doi: 10.1016/j.vaccine.2017.01.033. Epub 2017 Feb 3.
Emerging clade 2.3.4.4 of the highly pathogenic avian influenza (HPAI) virus strain H5N8, which had been detected sporadically in domestic poultry in China, started to affect wild birds and poultry in South Korea in 2014. The virus was spread to Germany, Italy, the Netherlands, United Kingdom, and even United States by migratory birds. Here, we tested currently used commercial clade 2.3.2 H5 vaccines to evaluate mortality, clinical signs, virus shedding, and histological damage after experimental infection of chickens with the clade 2.3.4.4 HPAI H5N8 virus. Although the vaccination protected chickens from death, it failed to prevent chickens from shedding the virus and from tissue damage according to histological examination. These results suggest that the use of appropriate vaccines that match the currently epidemic HPAI virus is recommended, and continuous HPAI surveillance and testing of currently used commercial vaccines should be performed.
高致病性禽流感（HPAI）病毒株H5N8的新出现分支2.3.4.4，此前在中国家禽中偶尔被检测到，于2014年开始影响韩国的野生鸟类和家禽。该病毒通过候鸟传播到德国、意大利、荷兰、英国，甚至美国。在此，我们测试了目前使用的2.3.2分支H5疫苗，以评估在用2.3.4.4高致病性禽流感H5N8病毒对鸡进行实验性感染后鸡的死亡率、临床症状、病毒脱落情况和组织学损伤。尽管接种疫苗可保护鸡免于死亡，但根据组织学检查，它未能防止鸡排出病毒和组织损伤。这些结果表明，建议使用与当前流行的高致病性禽流感病毒相匹配的合适疫苗，并应对当前使用的商业疫苗进行持续的高致病性禽流感监测和检测。
