整个青春期的身体活动与成年早期的糖化血红蛋白：队列研究
Physical Activity Throughout Adolescence and Hba1c in Early Adulthood: Birth Cohort Study.
作者信息
Nakamura Priscila M, Mielke Grégore I, Horta Bernardo L, Assunção Maria Cecília, Gonçalves Helen, Menezes Ana M B, Barros Fernando C, Ekelund Ulf, Brage Soren, Wehrmeister Fernando C, Oliveira Isabel O, Hallal Pedro C
出版信息
J Phys Act Health. 2017 May;14(5):375-381. doi: 10.1123/jpah.2016-0245. Epub 2017 Feb 7.
BACKGROUND
Physical inactivity is responsible for 7% of diabetes deaths worldwide, but little is known whether low levels of physical activity (PA) during adolescence increase the risk of diabetes in early adulthood. We evaluated the cross-sectional and longitudinal associations between PA throughout adolescence and HbA1c concentration in early adulthood.
METHODS
HbA1c was measured by high performance liquid chromatography. PA was assessed by self-report at the ages of 11, 15, and 18 years and by accelerometry at the ages of 13 (subsample) and 18 years. The loss percentages of follow up were 12.5% at 11 years, 14.4% at 15 years, and 18.7% at 18 years.
RESULTS
At 18 years, boys showed higher HbA1c than girls. At age 18 years, accelerometrybased PA at 18 years was inversely related to HbA1c levels in boys. Self-reported leisure-time PA at ages 11, 15, and 18 were unrelated to HbA1c in both genders. PA at 13 years of age was unrelated to HbA1c among both genders. In trajectory analysis, PA and accelerometer PA trajectories were not associated with later HbA1c.
CONCLUSIONS
Objectively measured PA at 18 years was cross-sectionally inversely associated with HbA1c in boys only. No prospective associations were identified.
背景
全球7%的糖尿病死亡病例归因于缺乏身体活动，但对于青少年时期低水平的身体活动（PA）是否会增加成年早期患糖尿病的风险，人们知之甚少。我们评估了整个青少年时期的PA与成年早期糖化血红蛋白（HbA1c）浓度之间的横断面和纵向关联。
方法
采用高效液相色谱法测量HbA1c。通过自我报告在11岁、15岁和18岁时评估PA，并在13岁（子样本）和18岁时通过加速度计评估PA。11岁时的随访失访率为12.5%，15岁时为14.4%，18岁时为18.7%。
结果
18岁时，男孩的HbA1c水平高于女孩。在18岁时，基于加速度计测量的18岁时的PA与男孩的HbA1c水平呈负相关。自我报告的11岁、15岁和18岁时的休闲时间PA与两性的HbA1c均无关。13岁时的PA与两性的HbA1c均无关。在轨迹分析中，PA和加速度计测量的PA轨迹与后期的HbA1c无关。
结论
仅在男孩中，客观测量的18岁时的PA与HbA1c呈横断面负相关。未发现前瞻性关联。
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