Chemical Neurobiology Laboratory, Center for Genomic Medicine, Chemical Biology Program, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts 02114, United States.
Centro de Investigaciones Biológicas-CSIC , Madrid 28040, Spain.
ACS Chem Neurosci. 2017 Mar 15;8(3):444-453. doi: 10.1021/acschemneuro.7b00018. Epub 2017 Feb 15.
The discovery of haloperidol catalyzed a breakthrough in our understanding of the biochemical basis of schizophrenia, improved the treatment of psychosis, and facilitated deinstitutionalization. In doing so, it solidified the role for chemical neuroscience as a means to elucidate the molecular underpinnings of complex neuropsychiatric disorders. In this Review, we will cover aspects of haloperidol's synthesis, manufacturing, metabolism, pharmacology, approved and off-label indications, and adverse effects. We will also convey the fascinating history of this classic molecule and the influence that it has had on the evolution of neuropsychopharmacology and neuroscience.
氟哌啶醇的发现推动了我们对精神分裂症生化基础的理解取得突破，改善了精神病的治疗效果，并促进了精神病院的去机构化。由此，它巩固了化学生物学作为阐明复杂神经精神疾病分子基础的一种手段的作用。在这篇综述中，我们将介绍氟哌啶醇的合成、制造、代谢、药理学、批准和非适应证以及不良反应等方面。我们还将传达这个经典分子的迷人历史及其对神经精神药理学和神经科学发展的影响。
