Department of Chemistry and Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States.
J Org Chem. 2017 Mar 3;82(5):2319-2328. doi: 10.1021/acs.joc.7b00009. Epub 2017 Feb 13.
Carbon monoxide is an important one-carbon source and can be incorporated in complex molecules via various transition-metal-catalyzed carbonylation reactions. In particular, palladium-catalyzed carbonylation reactions have found broad application in total synthesis of natural products. Examples are presented in this Synopsis to highlight recent progress in this area, including our own work in macrolide and spirocyclic molecule synthesis. In these selected cases, carbon monoxide functions as a one-carbon linchpin to facilitate building structural complexity and improving synthetic efficiency.
一氧化碳是一种重要的一碳源，可以通过各种过渡金属催化的羰基化反应将其掺入复杂分子中。特别是钯催化的羰基化反应在天然产物的全合成中得到了广泛的应用。本文通过实例来突出该领域的最新进展，包括我们在大环和螺环分子合成方面的工作。在这些选定的情况下，一氧化碳作为一个一碳桥接基团，有助于构建结构复杂性并提高合成效率。
