钯催化羰基化反应：在复杂天然产物全合成中的应用及最新进展。
Palladium-Catalyzed Carbonylations: Application in Complex Natural Product Total Synthesis and Recent Developments.
机构信息
Department of Chemistry, Emory University, Atlanta, Georgia30322, United States.
Department of Chemistry, Purdue University, West Lafayette, Indiana47907, United States.
出版信息
J Org Chem. 2023 Apr 21;88(8):4925-4941. doi: 10.1021/acs.joc.2c02746. Epub 2023 Jan 27.
Carbon monoxide is a cheap and abundant C1 building block that can be readily incorporated into organic molecules to rapidly build structural complexity. In this Perspective, we outline several recent (since 2015) examples of palladium-catalyzed carbonylations in streamlining complex natural product total synthesis and highlight the strategic importance of these carbonylation reactions in the corresponding synthesis. The selected examples include spinosyn A, callyspongiolide, perseanol, schizozygane alkaloids, cephanolides, and bisdehydroneostemoninine and related stemona alkaloids. We also provide our perspective about the recent advancements and future developments of palladium-catalyzed carbonylations.
一氧化碳是一种廉价且丰富的 C1 构建块，可以很容易地掺入有机分子中，从而快速构建结构复杂性。在本观点中，我们概述了几种最近（自 2015 年以来）钯催化羰基化反应在简化复杂天然产物全合成中的实例，并强调了这些羰基化反应在相应合成中的战略重要性。所选实例包括 Spinosyn A、Callyspongiolide、Perseanol、Schizozygane 生物碱、Cephanolides 和 Bisdehydroneostemoninine 以及相关的 Stemona 生物碱。我们还提供了关于钯催化羰基化反应的最新进展和未来发展的观点。
Zotero 插件