Stevens W J, van Bever H P
Immunology and Pediatrics, University of Antwerp, Belgium.
Allergy. 1989 Sep;44(7):471-6. doi: 10.1111/j.1398-9995.1989.tb04185.x.
The occurrence of late asthmatic reactions after bronchial allergen challenge was studied in 50 house dust mite allergic patients subdivided in three groups: one group had asthma without nasal symptoms, another group had rhinitis without pulmonary symptoms and a third group had a combination of both asthma and rhinitis. Late asthmatic reactions were present in 80% of asthmatic patients and in 18.7% of rhinitis patients. The degree of non-specific bronchial reactivity to histamine (provocative dose 15 or PD15 histamine) and the degree of immediate reactivity to allergen (PD15 house dust mite) did not differ significantly between patients with and without late asthmatic reactions. These findings suggest that an important difference between asthma and rhinitis is the lack of late asthmatic reactions in rhinitis patients, whereas the degree of immediate bronchial reactivity to the allergen is similar in asthma and rhinitis.
对50名屋尘螨过敏患者进行了研究，这些患者被分为三组，以观察支气管过敏原激发后迟发性哮喘反应的发生情况：一组患有哮喘但无鼻部症状，另一组患有鼻炎但无肺部症状，第三组同时患有哮喘和鼻炎。80%的哮喘患者和18.7%的鼻炎患者出现了迟发性哮喘反应。有和没有迟发性哮喘反应的患者之间，对组胺的非特异性支气管反应性程度（组胺激发剂量15或PD15组胺）以及对过敏原的即刻反应程度（PD15屋尘螨）没有显著差异。这些发现表明，哮喘和鼻炎之间的一个重要区别是鼻炎患者缺乏迟发性哮喘反应，而哮喘和鼻炎患者对过敏原的即刻支气管反应程度相似。
