Guijarro de Pablos J E, Gonzalez Sequeros O, Moral Rubio J R, Ramirez Gonzalez J A
Anat Histol Embryol. 1989 Sep;18(3):227-45. doi: 10.1111/j.1439-0264.1989.tb00599.x.
A light microscopic study of the epithelia of the crista ampullaris of the semicircular canals of the embryonic chicken indicates that the epithelial cells undergo irregular degenerative changes, with continual mitotic replacement of surface cells. The cupula develops over the surface epithelia through vesicular secretions containing acidophils fibrillar material mixed with globular formations derived from fragmentation of the surface epithelial cells. Electron microscopic studies demonstrate the mode of secretion of rounded or oval supraepithelial bodies from surface epithelium, contributing to the development of the cupula ampullaris. These observations provide evidence of cytoplasmic contributions of surface epithelial cells of the crista ampullaris contributing to the development and continued reorganization of the cupula ampullaris during embryonic development.
对胚胎期鸡半规管壶腹嵴上皮的光镜研究表明，上皮细胞会发生不规则的退行性变化，表面细胞不断通过有丝分裂进行替换。壶腹嵴帽通过含有嗜酸性纤维物质的囊泡分泌物在表面上皮上形成，这些分泌物中还混合有源自表面上皮细胞破碎的球状结构。电子显微镜研究显示了表面上皮分泌圆形或椭圆形上皮上体的方式，这有助于壶腹嵴帽的形成。这些观察结果提供了证据，表明壶腹嵴表面上皮细胞的细胞质成分在胚胎发育过程中对壶腹嵴帽的形成和持续重组有贡献。
