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Editorial: The HSP70 Molecular Chaperone Machines.社论：HSP70分子伴侣机器
Front Mol Biosci. 2017 Jan 24;4:1. doi: 10.3389/fmolb.2017.00001. eCollection 2017.
2
Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain.Apg2 调控人源 Hsc70 ATP 酶和分子伴侣活性：酸性结构域的作用
J Mol Biol. 2019 Jan 18;431(2):444-461. doi: 10.1016/j.jmb.2018.11.026. Epub 2018 Dec 4.
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Synergism between a foldase and an unfoldase: reciprocal dependence between the thioredoxin-like activity of DnaJ and the polypeptide-unfolding activity of DnaK.折叠酶和展开酶之间的协同作用：硫氧还蛋白样活性的 DnaJ 和多肽展开活性的 DnaK 之间的相互依赖关系。
Front Mol Biosci. 2014 Jul 31;1:7. doi: 10.3389/fmolb.2014.00007. eCollection 2014.
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Selective Hsp70-Dependent Docking of Hsp104 to Protein Aggregates Protects the Cell from the Toxicity of the Disaggregase.选择性依赖 Hsp70 的 Hsp104 与蛋白聚集体的对接可保护细胞免受解聚酶的毒性影响。
J Mol Biol. 2019 May 17;431(11):2180-2196. doi: 10.1016/j.jmb.2019.04.014. Epub 2019 Apr 24.
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Steered molecular dynamics simulation of the binding of the bovine auxilin J domain to the Hsc70 nucleotide-binding domain.牛辅助蛋白J结构域与热休克蛋白70（Hsc70）核苷酸结合结构域结合的引导分子动力学模拟
J Mol Model. 2017 Oct 23;23(11):320. doi: 10.1007/s00894-017-3453-2.
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A genomewide analysis of genes for the heat shock protein 70 chaperone system in the ascidian Ciona intestinalis.对海鞘肠鳃纲动物中海藻糖70伴侣系统基因的全基因组分析。
Cell Stress Chaperones. 2006 Spring;11(1):23-33. doi: 10.1379/csc-137r.1.
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The Complex Phosphorylation Patterns that Regulate the Activity of Hsp70 and Its Cochaperones.调控 Hsp70 及其共伴侣活性的复杂磷酸化模式。
Int J Mol Sci. 2019 Aug 23;20(17):4122. doi: 10.3390/ijms20174122.
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Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70.热休克蛋白90辅助伴侣亲环素40与热休克同源蛋白70的相互作用。
Cell Stress Chaperones. 2004 Summer;9(2):167-81. doi: 10.1379/csc-26r.1.
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Cellular Handling of Protein Aggregates by Disaggregation Machines.细胞通过解聚机器处理蛋白质聚集体。
Mol Cell. 2018 Jan 18;69(2):214-226. doi: 10.1016/j.molcel.2018.01.004.
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Metazoan Hsp70-based protein disaggregases: emergence and mechanisms.基于后生动物热休克蛋白70的蛋白质解聚酶：出现与机制
Front Mol Biosci. 2015 Oct 9;2:57. doi: 10.3389/fmolb.2015.00057. eCollection 2015.

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A Mesenchymal stem cell Aging Framework, from Mechanisms to Strategies.间充质干细胞衰老框架：从机制到策略
Stem Cell Rev Rep. 2024 Aug;20(6):1420-1440. doi: 10.1007/s12015-024-10732-4. Epub 2024 May 10.
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Real-time single-molecule observation of chaperone-assisted protein folding.实时单分子观察伴侣蛋白辅助的蛋白质折叠。
Sci Adv. 2022 Dec 14;8(50):eadd0922. doi: 10.1126/sciadv.add0922.
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Mitochondrial HSC70-1 Regulates Polar Auxin Transport through ROS Homeostasis in Arabidopsis Roots.线粒体热休克蛋白70-1通过拟南芥根中的活性氧稳态调节生长素极性运输。
Antioxidants (Basel). 2022 Oct 15;11(10):2035. doi: 10.3390/antiox11102035.
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Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from the Marine Annelid sp. onto Ovarian Cancer Cells.海洋环节动物 sp. 的蛋白毒素分泌物对卵巢癌细胞的特定抗增殖特性。
Mar Drugs. 2021 Jan 12;19(1):31. doi: 10.3390/md19010031.
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The expanding world of plant J-domain proteins.植物J结构域蛋白的扩展世界。
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Chaperome Networks - Redundancy and Implications for Cancer Treatment.伴侣蛋白组网络——冗余及其对癌症治疗的影响。
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Arabidopsis mtHSC70-1 physically interacts with the Cox2 subunit of cytochrome oxidase.拟南芥 mtHSC70-1 与细胞色素氧化酶的 Cox2 亚基发生物理相互作用。
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HSP70 is required for the proper assembly of pericentriolar material and function of mitotic centrosomes.HSP70是中心粒周围物质正确组装和有丝分裂中心体功能所必需的。
Cell Div. 2019 May 10;14:4. doi: 10.1186/s13008-019-0047-7. eCollection 2019.
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Nonspecific stress response to temperature increase in Sars with respect to oxygen-limited thermal tolerance concept.关于氧气限制热耐受性概念，Sars中对温度升高的非特异性应激反应。
PeerJ. 2018 Sep 17;6:e5571. doi: 10.7717/peerj.5571. eCollection 2018.
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Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells.蛋白质动态平衡（蛋白质稳态）的机制维持着哺乳动物多能干细胞的干细胞特性。
Cell Mol Life Sci. 2018 Jan;75(2):275-290. doi: 10.1007/s00018-017-2602-1. Epub 2017 Jul 26.

本文引用的文献

1
Unraveling the CHIP:Hsp70 complex as an information processor for protein quality control.解析 CHIP:Hsp70 复合物作为蛋白质质量控制的信息处理器。
Biochim Biophys Acta Proteins Proteom. 2017 Feb;1865(2):133-141. doi: 10.1016/j.bbapap.2016.11.005. Epub 2016 Nov 15.
2
Alternative modes of client binding enable functional plasticity of Hsp70.替代的客户绑定模式使 Hsp70 具有功能可塑性。
Nature. 2016 Nov 17;539(7629):448-451. doi: 10.1038/nature20137. Epub 2016 Oct 26.
3
Hsp70 chaperones use ATP to remodel native protein oligomers and stable aggregates by entropic pulling.热休克蛋白70伴侣蛋白利用三磷酸腺苷通过熵拉力重塑天然蛋白质寡聚体和稳定聚集体。
Nat Struct Mol Biol. 2016 Sep 6;23(9):766-9. doi: 10.1038/nsmb.3283.
4
Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation.网格蛋白包被的拆卸揭示了Hsp70产生力的机制。
Nat Struct Mol Biol. 2016 Sep;23(9):821-9. doi: 10.1038/nsmb.3272. Epub 2016 Aug 1.
5
Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer.用于癌症治疗的热休克蛋白-肽及基于热休克蛋白的免疫疗法
Front Immunol. 2016 Apr 29;7:171. doi: 10.3389/fimmu.2016.00171. eCollection 2016.
6
Cellular Homeostasis and Aging.细胞内稳态与衰老。
Annu Rev Biochem. 2016 Jun 2;85:1-4. doi: 10.1146/annurev-biochem-011116-110806. Epub 2016 Apr 6.
7
Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes.分子伴侣作为多肽解折叠酶的发现中的实验里程碑。
Annu Rev Biochem. 2016 Jun 2;85:715-42. doi: 10.1146/annurev-biochem-060815-014124. Epub 2016 Mar 31.
8
Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils.人类热休克蛋白70解聚酶可逆转与帕金森病相关的α-突触核蛋白淀粉样纤维。
Mol Cell. 2015 Sep 3;59(5):781-93. doi: 10.1016/j.molcel.2015.07.012. Epub 2015 Aug 20.
9
Quantitative proteomics of heat-treated human cells show an across-the-board mild depletion of housekeeping proteins to massively accumulate few HSPs.对热处理后的人类细胞进行定量蛋白质组学分析表明，管家蛋白普遍出现轻度减少，而少数热休克蛋白（HSP）则大量积累。
Cell Stress Chaperones. 2015 Jul;20(4):605-20. doi: 10.1007/s12192-015-0583-2. Epub 2015 Apr 8.
10
Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma.肿瘤组织中热休克蛋白（HSPA12A、HSP90B1、HSPA4、HSPA5 和 HSPA6）的上调与 HBV 相关早期肝细胞癌的不良预后相关。
Int J Med Sci. 2015 Feb 15;12(3):256-63. doi: 10.7150/ijms.10735. eCollection 2015.

Editorial: The HSP70 Molecular Chaperone Machines.

作者信息

Goloubinoff Pierre

机构信息

Department of Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne Lausanne, Switzerland.

出版信息

Front Mol Biosci. 2017 Jan 24;4:1. doi: 10.3389/fmolb.2017.00001. eCollection 2017.

DOI:10.3389/fmolb.2017.00001
PMID:28174697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5258742/
Abstract
摘要